出生年月：1990-01
民族：汉
职称：副教授（硕士研究生导师）
学科专业：真菌天然产物化学与合成生物学
邮箱：chenhp@mail.scuec.edu.cn
教育经历
2014.09–2017.07：中国科学院昆明植物研究所，理学博士
2011.09–2014.07：中国科学院昆明植物研究所，理学硕士
2007.09–2011.07：安徽医科大学，理学学士
工作经历
2024.05–至今：威尼斯wns8885556药学院，副教授（硕士研究生导师）
2017.07–2024.04：威尼斯wns8885556药学院，讲师（硕士研究生导师）
2019.11–2021.11：日本东京大学研究生院药学系JSPS博士后，合作导师：Ikuro Abe教授
学术兼职
Natural Products and Bioprospecting青年编委
个人主页：
ORCID: https://orcid.org/0000-0003-0416-9535
ResearchGate: https://www.researchgate.net/profile/He_Ping_Chen2
主持的科研项目：
1. 国家自然科学基金面上项目，82473810，2025.01–2028.12，在研
2. 国家自然科学基金青年项目，81903512，2020.01–2022.12，已结题
3. 湖北省自然科学基金青年基金项目，2019CFB379，2019.09–2021.09，已结题
4. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室开放基金项目，P2017-KF01，2018-2020，已结题
5. 北京大学天然药物及仿生药物国家重点实验室开放基金项目，K20180206，2018.12–2019.06，已结题
6. 中央高校基本科研业务费专项资金项目平台专项，CPT22033，2022.04–2024.04
7. 科技部外国专家引进计划，G2022185005L，真菌活性天然产物生物合成与合成生物学，2022.1–2023.12，已结题
代表性研究成果：
2024
1. Qing-Yuan Wang#, He-Ping Chen#,*, Haobo Tao#, Xinyang Li, Qianru Zhao*, Ji-Kai Liu*. Penidaleodiolides A and B, Cage-like Polyketides with Neurontransmission-Regulating Activity from the Soil Fungus Penicillium daleae L3SO. Org. Lett. 2024, 26, 7632–7637.
2. Qing-Yuan Wang#, Yang Gao#, Jian-Neng Yao, Li Zhou*, He-Ping Chen*, Ji-Kai Liu*. Penisimplicins A and B, novel polyketide-peptide hybrid alkaloids from the fungus Penicillium simplicissimum JXCC5. Molecules 2024, 29(3), 613.
2023
3. Jing Fan#, Pai Liu#, Kuan Zhao*, He-Ping Chen*. Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus. Nat. Prod. Bioprospect. 2023, 13:46.
4. Qian-Qian Meng, Shun-Yao Tong, Xing-Rong Peng, Yu-Qing Zhao, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima. Molecules 2023, 28, 2705. DOI:10.3390/molecules28062705.
2022
5. Lin Zhou#, He-Ping Chen#, Xinyang Li*, Ji-Kai Liu*. Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom Ganoderma australe. Pharmaceuticals 2022, 15, 1520.
6. Qing-Yuan Wang#, He-Ping Chen#, Kai-Yue Wu, Xinyang Li*, Ji-Kai Liu*. Antibacterial and β-amyloid precursor protein-cleaving enzyme 1 inhibitory polyketides from the fungus Aspergillus chevalieri. Front. Microbiol. 2022, 13, 1051281.
7. Xinyang Li#, He-Ping Chen#, Lin Zhou#, Jing Fan, Takayoshi Awakawa, Takahiro Mori, Richiro Ushimaru*, Ikuro Abe*, Ji-Kai Liu*. Cordycicadins A−D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1. Org. Lett. 2022, 24 (47), 8627–8632.
8. Lin Zhou#, Subiy Akbar#, Meng-Xi Wang, He-Ping Chen*, Ji-Kai Liu*. Tetra-, penta-, and hexa-nor-lanostane triterpenes from the medicinal fungus Ganoderma australe. Nat. Prod. Bioprospect. 2022, 12, 32.
9. Lin-Lin Yuan, Bao-Bao Shi, Tao Feng, Rong Huang, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. a-Glucosidase inhibitory phenylpropanoid-dihydrochalcone hybrids from the leaves of medicinal plant Malus hupehensis (Pamp.) Rehder. Phytochemistry 2022, 204, 113421.
10. Lin Zhou#, Li-Li Guo#, Masahiko Isaka, Zheng-Hui Li*, He-Ping Chen*. [20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe. J. Fungi, 2022, 8, 503.
11. Takahiro Mori#*, Yu Nakashima#, Heping Chen#, Shotaro Hoshino, Takaaki Mitsuhashi, Ikuro Abe*. Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation. Chem. Commun., 2022, 58, 5510-5513.
12. Hui Tao#, Takahiro Mori#*, Heping Chen, Shuang Lyu, Akihito Nonoyama, Shoukou Lee, Ikuro Abe*. Molecular Insights into the unusually promiscuous and catalytically versatile Fe(II)/-ketoglutarate-dependent oxygenase SptF. Nat. Commun., 2022, 13, 95.
13. Shui-Lin Liu#, Lin Zhou#, He-Ping Chen*, Ji-Kai Liu*. Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134. Phytochemistry, 2022, 195, 113048.
2021
14. Qing-Yuan Wang, He-Ping Chen*, Ji-Kai Liu*. Isopimarane Diterpenes from the Rice Fermentation of the Fungicolous Fungus Xylaria longipes HFG1018. Phytochem. Lett., 2021, 45, 100–104.
15. He-Ping Chen, Ikuro Abe*. Microbial Soluble Aromatic Prenyltransferases for Engineered Biosynthesis. Synth. Syst. Biotechnol., 2021, 6, 51–62.
16. Zhen-Zhu Zhao, Qi-Lu Zhao, Wei-Sheng Feng, Hai-Rong He, Meng Li, Gui-Min Xue, He-Ping Chen*, Ji-Kai Liu*. Absolute stereostructure assignments of ochracines F–L, chamigrane and cadinane sesquiterpenes from the basidiomycete Steccherinum ochraceum HFG119. RSC Adv., 2021, 11, 18693.
2020
17. He-Ping Chen, Zhen-Zhu Zhao, Gui-Guang Cheng, Kuan Zhao, Kai-Yue Han, Lin Zhou, Tao Feng, Zheng-Hui Li, Ji-Kai Liu*. Immunosuppressive nor-isopimarane diterpenes from cultures of the fungicolous fungus Xylaria longipes HFG1018. J. Nat. Prod. 2020, 83, 401–412.
18. He-Ping Chen, Jing Li, Zhen-Zhu Zhao, Xinyang Li, Shui-Lin Liu, Qing-Yuan Wang, Ji-Kai Liu*. Diterpenes with bicyclo[2.2.2]octane moieties from the fungicolous fungus Xylaria longipes HFG1018. Org. Biomol. Chem. 2020, 18, 2410–2415.
19. He-Ping Chen, Xu Ji, Zheng-Hui Li, Tao Feng, Ji-Kai Liu*. Irlactane and tremulane sesquiterpenes from the cultures of the medicinal fungus Irpex lacteus HFG1102. Nat. Prod. Bioprospect. 2020, 10, 89–100.
20. Zhen-Zhu Zhao, Xu-Bo Liang, Wei-Sheng Feng, Gui-Min Xue, Ying-Ying Si, He-Ping Chen*, Ji-Kai Liu*. Cyclic dipeptides with peroxy groups from the fruiting bodies of the edible mushroom Tricholoma matsutake. Tetrahedron Lett. 2020, 61, 151892.
21. Zhen-Zhu Zhao, Ji-Kai Liu, He-Ping Chen*. Microporotriol, a new cadinane-type sesquiterpenoid from the cultures of the wood-decay fungus Microporus affinis HFG829. Nat. Prod. Res. 2020, 34, 2194–2201.
2019
22. Yang Tang, Zhen-Zhu Zhao, Kun Hu, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Irpexolidal represents a class of triterpenoid from the fruiting bodies of the medicinal fungus Irpex lacteus. J. Org. Chem. 2019, 84, 1845–1852.
23. Yang Tang, Zhen-Zhu Zhao, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Triterpenes with unusual modifications from the fruiting bodies of the medicinal fungus Irpex lacteus. Phytochemistry 2019, 162, 21–28.
24. Zhen-Zhu Zhao, Kai-Yue Han, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Cytotoxic ergosteroids from the fungus Stereum hirsutum. Phytochemistry Lett. 2019, 30, 143–149.
25. Zhen-Zhu Zhao, Xu-Bo Liang, Wei-Sheng Feng, Ya Wu, Yan-Le Zhi, Gui-Min Xue, He-Ping Chen*, Ji-Kai Liu*. Unusual constituents from the medicinal mushroom Ganoderma lingzhi. RSC Adv. 2019, 9, 36931–36939.
26. Zhen-Zhu Zhao, Wei-Sheng Feng, Xu-Bo Liang, Gui-Min Xue, Ying-Ying Si, He-Ping Chen*, Ji-Kai Liu*. Ochracines A-E, chamigrane-related norsesquiterpene derivatives from the basidiomycete Steccherinum ochraceum HFG119. Fitoterapia 2019, 139, 104362.
27. Kai-Yue Han, Xing Wu, Chenglin Jiang, Rong Huang, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Three new compounds from the actinomycete Actinocorallia aurantiaca. Nat. Prod. Bioprospect. 2019, 9, 351–354.
28. Sheng-Xiang Yang, Wen-Ting Zhao, Heng-Ye Chen, Lei Zhang, Ting-Kai Liu, He-Ping Chen*, Jian Yang*, Xiao-Long Yang*. Aureonitols A and B, two new c13-polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza. Chem. & Biodivers. 2019, 16, e1900364.
2018
29. He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Ying Huang, Shuai-Bing Zhang, Yang Tang, Jian-Neng Yao, Lin Chen, Masahiko Isaka, Tao Feng*. Ji-Kai Liu*. Antiproliferative and anti-inflammatory lanostane triterpenoids from the Polish edible mushroom Macrolepiota procera. J. Agric. Food Chem. 2018, 66, 3146–3154.
30. He-Ping Chen, Meng-Yuan Jiang, Zhen-Zhu Zhao, Tao Feng, Zheng-Hui Li, Ji-Kai Liu*. Vibralactone biogenesis-associated analogues from submerged cultures of the Fungus Boreostereum vibrans. Nat. Prod. Bioprospect. 2018, 8, 37–45.
31. He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Seco-tremulane sesquiterpenoids from the cultures of the medicinal fungus Irpex lacteu HFG1102. Nat. Prod. Bioprospect. 2018, 8, 113–119.
32. Yang Tang, Zhen-Zhu Zhao, Jian-Neng Yao, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Irpeksins A–E, 1,10-seco-eburicane-type triterpenoids from the medicinal fungus Irpex lacteus and Their Anti-NO Activity. J. Nat. Prod. 2018, 81, 2163–2168.
33. Yang Tang, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Irpexoates A–D, four triterpenoids with malonyl modifications from the fruiting bodies of the medicinal fungus Irpex lacteus. Nat. Prod. Bioprospect. 2018, 8, 171–176.
2017
34. Zhen-Zhu Zhao#, He-Ping Chen#, Bin Wu, Ling Zhang, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Matsutakone and matsutoic acid, two (nor)steroids with unusual skeletons from the edible mushroom Tricholoma matsutake. J. Org. Chem. 2017, 82, 7974–7979 (Co-first author).
35. He-Ping Chen, Ji-Kai Liu*. Secondary Metabolites from Higher Fungi. Progress in the Chemistry of Organic Natural Products. Springer International Publishing AG 2017, Vol. 106, pp.1–201.
