李昕阳

发布时间:2024-03-29 浏览次数:

出生年月:1990-01

   族:汉

   称:副教授

学科专业:真菌天然产物化学与合成生物学

   箱:xinyangli@scuec.edu.cn

 

教育经历

2015.09-2019.06:浙江大学,医学博士

2012.09-2015.06:南京中医药大学,医学硕士

2008.09-2012.06:陕西中医药大学,医学学士

 

工作经历

2023.07至今:威尼斯wns8885556药学院,副教授

2019.09-2022.03,东京大学,博士后,合作导师:Ikuro Abe教授

 

主要研究方向

1.   真菌天然产物生物合成途径解析

2.   真菌天然产物生物合成酶学机制研究

3.   基于基因组挖掘手段的天然产物发现及其生物合成研究

 

科研项目

国家自然科学基金青年基金项目(22307148),2024.01-2026.12,主持

 

代表性研究成果

1.    Xinyang Li, Jinzhong Xu*, Pinmei Wang, Wanjing Ding. Novel Indole Diketopiperazine Stereoisomers from a Marine-Derived Fungus Aspergillus sp. Mycology. 2023, 14, 1-10.

2.    Xinyang Li, He-Ping Chen, Lin Zhou, Jing Fan, Takayoshi Awakawa, Takahiro Mori, Richiro Ushimaru*, Ikuro Abe*, Ji-Kai Liu*. Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1. Org. Lett. 2022, 24, 8627-8632.

3.    Qing-Yuan Wang, He-Ping Chen, Kai-Yue Wu, Xinyang Li*, Ji-Kai Liu*. Antibacterial and β-Site amyloid precursor protein cleaving enzyme 1 inhibitory polyketides from the fungus Aspergillus chevalieri. Front. Microbiol. 2022, 13, 1051281.

4.    Lin Zhou, He-Ping Chen, Xinyang Li*, Ji-Kai Liu*. Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom Ganoderma australe. Pharmaceuticals. 2022, 15, 1520.

5.    Xinyang Li, Takayoshi Awakawa, Takahiro Mori, Meiqi Ling, Bin Wu, Ikuro Abe*. Heterodimeric Non-heme Iron Enzymes in Fungal Meroterpenoid Biosynthesis. J. Am. Chem. Soc. 2021, 143, 21425-21432.

6.    Xinyang Li, Jian-ming Lv, Dan Hu, Ikuro Abe*. Biosynthesis of Alkyne-containing Natural Products. RSC Chem. Biol. 2021, 2, 166-180.

7.    Suoyu Cen, Jia Jia, Yichao Ge, Yihan Ma, Xinyang Li, Jihua Wei, Yuefan Bai, Xiaodan Wu, Jianfeng Song, Hongkai Bi, Bin Wu*. A New Antibacterial 3,5-dimethylorsellinic Acid-based Meroterpene from the Marine Fungus Aspergillus sp. CSYZ-1. Fitoterapia, 2021, 152, 104908.

8.    Jinyan Jiang, Xinyang Li, Takahiro Mori, Takayoshi Awakawa*, Ikuro Abe*. Novel Cyclohexyl Meroterpenes Produced by Combinatorial Biosynthesis. Chem. Pharm. Bull., 2021, 69, 444-446.

9.    Xinyang Li, Wanjing Ding, Pinmei Wang, Jinzhong Xu*. Two Novel Aspochalasins from the Gut Fungus Aspergillus sp. Z4. Mar. Drugs, 2018, 16, 343.

10. Xinyang Li, Zhanhai Zhao, Wanjing Ding, Bin Ye, Pinmei Wang, Jinzhong Xu*. Aspochalazine A, a Novel Polycyclic Aspochalasin from the Fungus Aspergillus sp. Z4. Tetrahedron Lett, 2017, 58, 2405-2408.

(Co-first author; *Corresponding author)

 

作者:   责编:陈博   审核:   上传:

地址:中国-湖北-武汉 民族大道182号威尼斯wns8885556药学院 邮编:430074
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