出生年月:1984-09
民族:汉
职称:讲师
学科专业:药剂学
邮箱:kangli_0926@163.com
教育经历:
2013.9-2017.6 :华中科技大学同济医学院,医学博士
2007.9-2010.6: 四川大学华西药学院,医学硕士
2003.9-2007.6: 重庆医科大学药学院,理学学士
工作经历:
2010.9-2013.7:江苏恒瑞医药股份有限公司,项目负责人
2018.3至今: 威尼斯wns8885556药学院,讲师
主要研究方向:
1. 靶向纳米药物传递系统的研究
2. 药物性肝损伤机制研究
科研项目:
1. Toll样受体9介导的信号通路在何首乌致肝损伤中的作用和机制研究,湖北省自然科学基金青年项目(2020CFB351),2020-2022,主持
2. 负载姜黄素的pH敏感水凝胶通过NEDD4介导PTGS2降解缓解铁死亡治疗炎症性肠病的机制研究(CZQ22009),中央高校基本科研业务费专项资金自科青年项目,主持
3. 何首乌致肝损伤的机理研究(YZZ18017),校科学基金项目,主持
4. 口服多生物响应性双层微凝胶用于溃疡性结肠炎的治疗(CZZ21010),中央高校基本科研业务费专项资金自科重点项目,主要参与人
5. 中药蕲艾精油包埋技术及经皮给药系统的研究与开发(QZY19001),地厅级自科一般项目,主要参与人
6. 民族药药效物质基础(YZF20004),“国家基金申报学术工作坊”自科项目,主要参与人
代表性研究成果:
(1) Kang Li#; Si Luqin#; Rao Jing; Li Dan; Wu Ya; Wu Sanlan; Wu Minghui; He Sijie; Zhu Wenwen;Wu Yang; Xu Jiaqiang; Li Gao; Huang Jiangeng ; Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes, Toxicology in Vitro, 2017, 40:313-323
(2) Zhang Shangwen#; Kang Li#; Hu Sheng; Hu jie; Fu Yanping; Hu Yan; Yang Xinzhou ;Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease, International Journal of Biological Macromolecules, 2021, 167: 1598-1612
(3) Hu Yan; Zhang Shangwen; Wen Zhijie; Fu Hudie; Hu jie; Ye Xuexin; Kang Li; Li Xiaojun;Yang Xinzhou ; Oral delivery of curcumin via multi-bioresponsive polyvinyl alcohol and guar gum based double-membrane microgels for ulcerative colitis therapy, International journal of biological macromolecules, 2022, 221(11): 806-820
(4) Kang Li#; Li Dan#; Jiang Xin#; Zhang Yao; Pan Minhong; Hu Yixin; Si Luqin; Zhang Yongjun;Huang Jiangeng ; Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis, Frontiers in Pharmacology, 2022, 13
(5) Zhijie Wen#; Li Kang#; Hudie Fu; Shengpeng Zhu; Xuexin Ye; Xuedan Yang; Shangwen Zhang; Jie Hu; Xiaojun Li; Lvyi Chen; Yan Hu; Xinzhou Yang ; Oral delivery of porous starch-loaded bilayer microgels for controlled drug delivery and treatment of ulcerative colitis, Carbohydrate Polymers, 2023, 314: 120887
(6) Hu Yan, Zhu Shengpegn, Ye Xue, Wen Zhijie, Fu Hudie, Kang Li, Aikemu A, Yang Xinzhou. Oral delivery of sodium alginate/chitosan bilayer microgels loaded with Lactobacillus rhamnosus GG for targeted therapy of ulcerative colitis. Int J Biol Macromol. 2024 Oct;278(Pt 3):134785.
(7) Hu Jie; Wen Zhijie; Fu Hudie,;Yang Xinzhou, Zhu Shengpeng, Kang Li, Yang Xinzhou, Hu Yan. Construction of redox-sensitive liposomes modified by glycyrrhetinic acid and evaluation of anti-hepatocellular carcinoma activity. Chem Phys Lipids. 2023 May;252:105292.