基本信息
性别: 男
政治面貌: 中共党员
出生日期: 02/16/1992
电子邮箱: hm19920216@126.com
ORCID: 0000-0002-7669-7364
教育及工作经历
2024.9 - 至今 ：威尼斯wns8885556药学院，讲师
2023.10 - 2024.9：武汉朗来科技发展有限公司， 先后任转化医学项目负责人、体外高级研究员
2019.5 - 2019.11：美国哈佛-麻省理工-博德研究所，联培博士，合作导师：Melina Claussnitzer教授
2018.10 - 2023.6：瑞典隆德大学医学院，博士，导师：Sebastian Kalamajski研究员，Paul Franks教授，Hindrik Mulder 教授
2018.1 - 2018.10：瑞典隆德大学医学院，研究助理，导师：Paul Franks教授
2014.9 - 2017.6：威尼斯wns8885556药学院，硕士
2010.9 - 2014.6：威尼斯wns8885556药学院，学士
研究兴趣
[1] 功能基因组学 - 基因与环境, 基因与药物相互作用对肥胖和2型糖尿病的影响的分子机制研究
[2] 肥胖和2型糖尿病的致病基因及其分子机制研究
[3] 天然产物的高通量抗糖尿病活性筛选的细胞模型构建
[4] 民族药来源的天然药物抗2型糖尿病和肥胖的活性与作用机制研究
参与项目
[1] Novel Approach to Systematically Characterize Exercise- and Nutrient-responsivegenes in Type 2 diabetes and cardiovascular disease，1545万人民币，欧盟研究委员会，2017.2-2024.1 (主要参与人)
[2] Precision medicinsk livstil som metod för förebyggande av typ 2-diabetes，330万人民币，瑞典研究委员会，2020.1-2024.1 (主要参与人)
[3] Investigation of genetic variants in MTIF3, relevant for personalised obesity treatment，14万人民币，Crafoordska stiftelsen基金会，2021.8-2023.6 (主要参与人)
[4] Creating a human disease in a dish model of diabetes by genetically engineering iPSCs using CRISPR/Cas9，35万人民币，Crafoordska stiftelsen基金会，2019.6-2021.6 (主要参与人)
[5] 基于GLUT4和SGLT2双靶点的槐属药用植物抗糖尿病药效物质基础及作用机制研究，66万人民币，国家自然科学基金委员会，2016.1-2019.12 (主要参与人)
论文发表
以第一作者发表论文11篇，其中在自然指数期刊发表2篇，中科院1区TOP期刊发表5篇，中科院2区期刊发表3篇，中科院3区期刊发表2篇，中科院4区期刊发表1篇，具体如下：
[1] Mi Huang, Daniel Coral, Hamidreza Ardalani, Peter Spegel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W Franks*, Sebastian Kalamajski*. Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function. Elife, 12: e84168.（中科院1区，Top期刊，Nature指数收录, IF: 7.7）
[2] Mi Huang, Melina Claussnitzer, Alham Saadat, Daniel E. Coral, Sebastian Kalamajski*, Paul W. Franks*. Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover. Diabetologia, 2023, 66: 1289-1305. （中科院1区，Top期刊，被评为亮点文章， IF: 8.2）
[3] Mi Huang, Rashmi B. Prasad, Daniel E. Coral, Line Hjort, Daniel T. R. Minja, Hindrik Mulder, Paul W. Franks*, Sebastian Kalamajski*. Human Genetic Variation at rs10071329 Correlates with Adiposity-related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function. Diabetes, 2024: db230531.（ 中科院1区，Top期刊，被评为亮点文章， IF: 7.7）
[4] Zhou, Qianying#, Mi Huang#, Yongcun Shen, Zhenling Chen, Liying Xu, and Zhigang Yang.Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4+1] Annulation of Difluorocarbene and Antitumor Activity Evaluation. Organic Letters, 2024, 26, 6, 1212–1217. (中科院1区，Nature指数收录，Top期刊，#并列一作，IF: 5.2)
[5] Xinzhou Yang#, Mi Huang#, Jie Yang, Jialin Wang, Sijian Zheng, Xinhua Ma, Jinyan Cai, Shihao Deng, Guangwen Shu, Guangzhong Yang*. Activity of isoliensinine in improving the symptoms of type 2 diabetic mice via activation of AMP-activated kinase and regulation of PPARγ. Journal of Agricultural and Food Chemistry, 2017, 65: 7168-7178. (中科院1区，Top期刊，#并列一作，IF: 6.1)
[6] Mi Huang, Ping Zhao, Mingrui Xiong, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, Xinzhou Yang, Tong-Cun Zhang. Antidiabetic activity of perylenequinonoid-rich extract from Shiraia bambusicola in KK-Ay mice with spontaneous type 2 diabetes mellitus. Journal of Ethnopharmacology, 2016, 191: 71-81. (中科院2区，Top期刊，IF: 5.24)
[7] Mi Huang#, Shihao Deng#, Qianqian Han, Ping Zhao, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, Xinzhou Yang*. Hypoglycemic activity and the potential mechanism of the flavonoid rich extract from Sophora tonkinensis Gagnep. in KK-Ay mice. Frontiers in Pharmacology, 2016, 7:288. (中科院2区，Top期刊，#并列一作，IF: 5.60)
[8] Li Chen#, Sijian Zheng#, Mi Huang#, Xinhua Ma, Jie Yang, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*. β-Ecdysterone from Cyanotis arachnoidea exerts hypoglycemic effects through activating IRS-1/Akt/GLUT4 and IRS-1/Akt/GLUT2 signal pathways in KK-Ay mice. Journal of Functional Foods, 2017, 39: 123-132. (中科院2区，Top期刊，#并列一作，IF: 5.60)
[9] Xinzhou Yang#, Mi Huang#, Sijian Zheng, Xinhua Ma, Dingrong Wan, Yunjiang Feng*. Liquid chromatography with mass spectrometry and NMR spectroscopy based discovery of cytotoxic principles from Daphne tangutica Maxim. Journal of Separation Science, 2016, 39: 2179-2187. (中科院3区，#并列一作，IF: 3.10)
[10] Jialin Wang#, Mi Huang#, Jie Yang, Xinhua Ma, Sijian Zheng, Shihao Deng, Yun Huang, Xinzhou Yang, Ping Zhao*. Anti-diabetic activity of stigmasterol from soybean oil by targeting GLUT4 glucose transporter. Food & Nutrition Research, 2017, 61: 1364117. (中科院4区，#并列一作，IF: 3.30)
[11] Xinzhou Yang#, Mi Huang#, Jinyan Cai, Dan Lv, Jingnan Lv, Sijian Zheng, Xinhua Ma, Ping Zhao, Qiang Wang. Chemical profiling of anti-hepatocellular carcinoma constituents from Caragana tangutica Maxim. by off-line semi-preparative HPLC-NMR. Natural Product Research, 2017, 31: 1150-1155. (中科院3区，#并列一作，IF: 2.20)
以共同作者参与发表论文18篇，在中科院1区期刊发表1篇，中科院2区期刊发表4篇，仅列举Top期刊如下：
[1] Sebastian Kalamajski, Mi Huang, Jonathan Dalla-Riva, Maria Keller, Adem Y Dawed, Ola Hansson, Ewan R Pearson, MetGen Plus Consortium, Hindrik Mulder, Paul W Franks*. Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression. Human Molecular Genetics, 31: 491-498.（中科院2区，Top期刊， IF: 3.5）
[2] Sevda Gheibi, Luis Rodrigo Cataldo, Alexander Hamilton, Mi Huang, Sebastian Kalamajski, Malin Fex, Hindrik Mulder*. Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes. Diabetes, 72: 491-498.（中科院1区，Top期刊，IF: 7.7）
[3] Jie Yang, Hao Chen, Qiang Wang, Shihao Deng, Mi Huang, Xinhua Ma, Ping Song, Jingwen Du, Yun Huang, Yanzhang Wen, Yongshen Ren, Xinzhou Yang*. Inhibitory effect of kurarinone on growth of human non-small cell lung cancer: an experimental study both in vitro and in vivo studies. Frontiers in Pharmacology, 2018, 9: 252.（中科院2区，Top期刊，IF: 5.60）
