姓名:沈金花
出生年月:1975年5月
职务/职称:教授,硕士生导师,博士生导师
通讯地址:威尼斯wns8885556生命科学学院8-B-202
E-mail:2011084@mail.scuec.edu.cn
一、学习及工作简历
1、1994.9- 1998.7: 湖北师范学院,生物教育专业,获理学学士学位。
2、1998.9—2001.7: 华中农业大学,生物化学与分子生物学专业,获理学硕士学位。
3、2001.9—2004.7: 中国协和医科大学,生物化学与分子生物学专业,获理学博士学位。
4、2006.2-2011.2:美国Case Western Reserve University医学院,从事博士后研究。
5、2011.08-至今:威尼斯wns8885556生命科学学院,工作。
二、主要社会兼职
湖北省及武汉市生物化学与分子生物学学会常务理事
三、科研活动及成果:
(一)主要研究方向
药物筛选与哮喘防治;疾病相关基因的功能研究。
(二)主持的科研项目
1.国家自然科学基金面上项目 (批准号: 31771274):MTMR14基因缺失增强哮喘气道高反应及其机理研究。执行年限:2018.01-2021.12. 资助经费:72万元。
2.国家自然科学基金面上项目(批准号: 81170227):磷酸肌醇磷酸酶MTMR14对心肌肥厚的影响及分子机制研究。执行年限:2012.01-2015.12。资助经费:57万元。
3.作为合作单位承担国家科技支撑计划子项目一项(批准号:2012BAI39B01):建立基因工程小鼠模型新品系。执行年限:2012.01-2014.12。资助经费:60万元。
4.湖北省杰出青年基金项目(批准号:2012FFA028):新型磷酸酶MTMR14在动脉粥样硬化中的作用及其机制研究,2013.01-2015.12。资助经费:10万元。
5.留学回国人员科技活动项目择优资助项目(优秀类)。资助经费:8万元。
6.免疫类体外诊断试剂原材料性能评价体系建立及实施项目。横向项目。执行年限:2021.12-2024.12.合同经费:50万元。
7.免疫类体外诊断试剂盒的研发。横向项目。执行年限:2023.10-2025.10.合同经费17万元。
(三)代表性论文
1. PP121, a dual inhibitor of tyrosine and phosphoinositide kinases relieves airway hyperresponsiveness, musus hypersecretion and inflammation in a murine asthma model. Wei Li#, Lu Xue#, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang and Jinhua Shen*. Molecular Medicine. 2023 Nov 7;29(1):154. doi: 10.1186/s10020-023-00748-w.
2. Duloxetine HCl alleviates asthma symptoms by regulating PI3K/AKT/mTOR and Nrf2/HO-1 signaling pathways. Changsi Peng#, Lu Xue#, Yanling Yue, Weiwei Chen, Wenyi Wang and Jinhua Shen*. Inflammation. 2023 Dec;46(6):2449-2469. doi: 10.1007/s10753-023-01892-5.
3. Shunbo Shi#, Lu Xue#, Shuhui Han, Haiting Qiu, Yongbo Peng, Ping Zhao, Qing-Hua Liu, Jinhua Shen*. Anti-contractile and anti-inflammatory effects of diacerein on isolated mouse airways smooth muscle and mouse asthma model. Front. Pharmacol. 2020, Sep 4; 11:560361. doi: 10.3389/fphar.2020.560361.
4. Wen N#, Xue L#, Yang Y, Shi S, Liu QH, Cai C, Shen J*. Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs. Biosci Rep. 2020 Feb 28:40(2). doi: 10.1042/BSR20190534.
5. Chen C#, Yang Y#, Yu MF#, Shi S, Han S, Liu QH, Cai C, Shen J*. Relaxant action of diclofenac sodium on mouse airway smooth muscle. Front Pharmacol. Jun 18:10:608, 2019. doi: 10.3389/fphar.2019.00608.
6. Yang Y#, Chen WW#, Wen N, Cai C, Liu Q-H, Shen J*. Benidipine, an anti-hypertensive drug, relaxes mouse airway smooth muscle. Life Sciences. 2019, 227: 74-81. doi: 10.1016/j.lfs.2019.04.036.
7. Wen N#, Yu MF#, Liu J#, Cai C, Liu QH, Shen J*. Deficiency of MTMR14 impairs male fertility in Mus musculus. PLoS One. 2018 Nov 9;13(11):e0206224. doi: 10.1371/journal.pone.0206224. eCollection 2018.
8. Jun Huang#, Liqun Ma#, Yongle Yang, Nana Wen, Wan Zhou, Congli Cai, Qing-Hua Liu and Jinhua Shen*. Chloroform extract of Artemisia annua L. (CEAA) relaxes mouse airway smooth muscle. Evidence-Based Complementary and Alternative Medicine. 2017 Nov 12;2017:9870414. doi: 10.1155/2017/9870414 (SCI, IF:2.175).
9. Xiao Yang#, Meng-Fei Yu#, Jun Lei#, Yong-Bo Peng, Ping Zhao, Lu Xue, Weiwei Chen, Li-Qun Ma, Qing-Hua Liu, Jinhua Shen*.Nuciferine relaxes tracheal rings via the blockade of VDLCC and NSCC channels. Planta Medica. 2018 Jan. 84(2):83-90 . doi: 10.1055/s-0043-118178. (SCI, IF:2.342).
10. Honghao Tan#, Jun Lei#, Lu Xue#, Congli Cai, Qing-hua Liu, Jinhua Shen*. Relaxing effects of TSU-68, an antiangiogenic agent, on mouse airway smooth muscle. Cellular Physiology and Biochemistry. 2017 Apr 27; 41(6):2350-2362. doi: 10.1159/000475653. (SCI, IF:4.465).
11. Xiao Yang#, Lu Xue#, Qingyang Zhao, Congli Cai, Qing-Hua Liu* and Jinhua Shen*. Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction. BMC Complementary and Alternative Medicine. 2017 Mar 20; 17(1):159. doi: 10.1186/s12906-017-1674-7. (SCI, IF:1.877).
12. Yin L#, Yong-Bo P#, Meng-Fei Y, Weiwei C, Ping Z, Lu X, Li-Qun M, Congli C, Qing-Hua L*, Jinhua S*. Mice lacking myotubularin-related protein 14 show accelerated high-fat diet-induced lipid accumulation and inflammation. J Physiol Biochem. 2016 Nov 2. doi: 10.1007/s13105-016-0520-6. (SCI, IF:2.054).
13. Yin Lv#, Lu Xue# Congli Cai, Qing-Hua Liu, and Jinhua Shen*. Deficiency of Myotubularin-related Protein 14 Influences Body Weight, Metabolism, and Inflammation in an Age-dependent Manner. Cell & Bioscience. 2015, Dec, 21, 5(69):1-15, DOI 10.1186/s13578-015-0062-6. (SCI, IF:3.63)
14. Jing Liu#, Yin Lv#, Qing-Hua, Liu, Cheng-kui Qu, Jinhua Shen*. Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts. Molecular and Cellular Biochemistry. 2014 Jul;392(1-2):31-7. doi: 10.1007/s11010-014-2015-5. (SCI, IF:2.3)
15. Congli Cai#, Jing Liu#, Chao Wang, and Jinhua Shen*. KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosis, DNA and Cell Biology, 2012 Sep, 31(9): 1447-1457. (SCI, IF: 2.159)
16. .Zheng H, Yu WM, Shen J, Kang S, Hambardzumyan D, Li JY, Shen Y, Kenney AM, Chen J, Qu CK*. Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development. Sci Adv. 2018 Oct 10;4(10):eaat2681. doi: 10.1126/sciadv.aat2681. eCollection 2018 Oct.
1. Yu WM, Liu X, Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu CK*. Metabolic regulation by the mitochondrial phosphatase ptpmt1 is required for hematopoietic stem cell differentiation, Cell Stem Cell, 2013 Jan 3;12(1):62-74. (SCI, IF: 27.49)
2. Shen Jinhua#, Xia Liu#, Wen-Mei Yu#, Liu J, Nibbelink MG, Guo C, Finkel T, Qu CK*. A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Molecular and Cellular Biology, 2011 Dec, 31 (24): 4902-4916. (*Equal authors) (SCI, IF: 6.188; ISSN 0270-7306)
3. Shen Jinhua#, Yu Wen-mei#, Brotto Marco#,Scherman JA, Guo C, Stoddard C, Nosek TM, Valdivia HH, Qu CK*. Deficiency of MIP phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis. Nature Cell Biology, 2009 Jun, 11(6): 769-76. (*Equal authors) (SCI, IF: 19.4; ISSN 1465-7392)
4. Sandra Romero-Suarez#, Shen Jinhua#, Leticia Brotto#, Hall T, Mo C, Valdivia HH, Andresen J, Wacker M, Nosek TM, Qu CK, Brotto M*. Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its lose accelerates skeletal muscle aging process by altering calcium homeostasis. Aging, 2010 Aug, 2(8): 504-513. (*Equal authors) (SCI, IF: 2.964; ISSN 1945-4589)
(四)授权发明专利
1. 萝芙木乙醇提取物在制备用于舒张预收缩的气管平滑肌药物中的应用。沈金花,李威。专利授权号:ZL 2021 1 0112926.X。专利授权日:2022.06.07。
2. 白鲜碱在制备用于舒张预收缩的气管平滑肌方面的药物中的应用。沈金花,韩淑慧。专利授权号:ZL 2019 1 1414040.X。专利授权日:2020.12.22。
3. 一种青蒿氯仿提取物及其制备方法和用途。沈金花,黄俊。专利授权号:ZL 2017 1 0154371.9。专利授权日:2020.7.17。
4. 一种以箬叶或箬叶提取物为活性成分的药物。沈金花,谭鸿浩。专利授权号:ZL 2017 1 0044938.7。专利授权日:2020.3.27。
5. 一种检测人类EGFR基因L861Q位点突变的探针和引物组合。沈金花,黄俊。专利授权号:ZL 2015 1 0992676.8。专利授权日:2019.1.11。
四、教学活动及其成果
(一)承担课程(本科生、研究生)
《动物学》理论课及实验课,本科生;
《高级动物发育生物学》,研究生;
《高级分子免疫学》,研究生;
《高级分子生物学》,研究生。