Education
2000-2004: B.S., College of Life Sciences, Northwest A&F University.
2004-2009: M.S. & Ph.D., The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, CAS.
Professional Experiences
2019.3-present: Professor, School of Pharmaceutical Science, South-Central University for Nationalities
2016.2-2019.2: Professor, School of Pharmaceutical Science, Chongqing University
2014.5-2015.5: Postdoctoral Fellow, Institute of Organic Chemistry, Hannover University
2012.4-2014.4: JSPS Fellow, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2009.9-2016.1: Associate Professor, College of Pharmaceutical Science, Hebei University
Research Interests
[1] Multiple strategies-guided fungal natural products discovery from fungi of unique ecological niches and their biological function investigations.
[2] The biosynthesis of fungal natural products (genome mining, engineered biosynthesis).
Selected Recent Publications
[1] Xiao-Long Yang, Steffen Friedrich, Sen Yin, Oliver Piech, Katherine Williams, Thomas J. Simpson, Russell J. Cox*. Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase. Chemical Science, 2019, 10, 8478–8489.
[2] Lu-Lin Xu#, Hai-Li Chen#, Ping Hai, Yuan Gao, Chuan-Dong Xie, Xiao-Long Yang*, Ikuro Abe*. (+)- and ()-Preuisolactone A: A pair of caged norsesquiterpenoidal enantiomers with a tricyclo[4.4.01,6.02,8]decane carbon skeleton from the endophytic fungus Preussia isomera. Organic Letters, 2019, 21, 10781081.
[3] Lu-Lin Xu, Ping Hai, Shuai-Bing Zhang, Jing-Fang Xiao, Yuan Gao, Bing-Ji Ma, Hai-Yan Fu*, Ye-Miao Chen*, Xiao-Long Yang*. Prenylated Indole Diterpene Alkaloids from a Mine Soil-derived Tolypocladium sp. Journal of Natural Products, 2019, 82: 221-231.
[4] Heng-Ye Chen#, Ting-Kai Liu#, Jian Yang,* Xiao-Long Yang*. Emerones A-C: Three novel merosesquiterpenoids with unprecedented skeletons from Emericella sp. XL029. Organic & Biomolecular Chemistry, 2019, 17: 8450 -8455.
[5] Sheng-Xiang Yang#, Wen-Ting Zhao#, Heng-Ye Chen, Lei Zhang, Ting-Kai Liu, He-Ping Chen*, Jian Yang*, Xiao-Long Yang*. Two new C13-polyketides from Chaetomium globosum, an endophytic fungus in Salvia miltiorrhiza. Chemistry & Biodiversity, 2019, 16: e1900364.
[6] Sheng-Xiang Yang#, Jing-Fang Xiao#, Ting-Kai Liu, Ze-Diao Huang, Xiang Li, Ye-Miao Chen*, Xiao-Long Yang*. Epitajixanthone hydrate: A new inhibitor of cancer cell growth and invasion. Anti-cancer Drugs, 2019, in press.
[7] Wei Zhao, Hai-Li Chen, Liu Hong, Xia Zhang, Xian-Jun Jiang, Dong-Lai Zhu*, Fei Wang*, Xiao-Long Yang*. Five new polyphenolic derivatives with antimicrobial activities from the root barks of Periploca sepium. Fitoterapia, 2019, 137: 104254.
[8] Heng-Ye Chen, Ting-Kai Liu, Qiong Shi, Xiao-Long Yang*. Sesquiterpenoids and diterpenes with antimicrobial activity from Leptosphaeria sp. XL026, an endophytic fungus in Panax notoginseng. Fitoterapia, 2019, 137: 104243.
[9] Lu-Lin Xu#, Xue-Jiao Pang#, Qiong Shi, Peng-Jie Xian, Yan-Duo Tao*, Xiao-Long Yang*. Two new prenylated indole diterpenoids from Tolypocladium sp. and their antimicrobial activities. Chemistry & Biodiversity, 2019, 16: e1900116.
[10] Wen-Ting Zhao#, Xiong Shi#, Peng-Jie Xian, Zhang Feng*, Jian Yang*, Xiao-Long Yang*. A new fusicoccane diterpene and a new polyene from the plant endophytic fungus Talaromyces pinophilus and their antimicrobial activities. Natural Product Research, 2019, doi: 10.1080/14786419.2019.1616727.
[11] Dan Xu, Xia Zhang, Xiong Shi, Peng-Jie Xian, Liu Hong, Yan-Duo Tao*, Xiao-Long Yang*. Two new cytochalasans from the marine sediment-derived fungus Westerdykella dispersa and their antibacterial activities. Phytochemistry Letters, 2019, 32: 52-55.
[12] Xia Zhang#, Hai-Li Chen#, Liu Hong, Lu-Lin Xu, Xiao-Wei Gong, Dong-Lai Zhu, Xiao-Hua Xu, Wei Zhao*, Fei Wang*, Xiao-Long Yang*. Three new hopane-type triterpenoids from the aerial part of Adiantum capillus-veneris and their antimicrobial activities. Fitoterapia, 2019, 133: 146-149.
[13] Ting Zhao, Lu-Lin Xu, Yan Zhang, Zheng-Hong Lin, Tao Xia, Deng-Feng Yang*, Ye-Miao Chen*, Xiao-Long Yang *. Three new α-pyrone derivatives from the plant endophytic fungus Penicillium ochrochloronthe and their antibacterial, antifungal and cytotoxic activities. Journal of Asian Natural Products Research, 2019, 21: 851-858.
[14] Xue-Jiao Pang, Shuai-Bing Zhang, Peng-Jie Xian, Xia Wu, Deng-Feng Yang*, Hai-Yan Fu*, Xiao-Long Yang*. Emericellins A and B: Two sesquiterpenoids with an unprecedented tricyclo[4,4,2,1]hendecane scaffold from the liquid cultures of endophytic fungus Emericella sp. XL 029. Fitoterapia, 2018, 131: 55-58.
[15] Wei Zhao, Lu-Lin Xu, Xia Zhang, Xiao-Wei Gong, Dong-Lai Zhu, Xiao-Hua Xu, Fei Wang*, Xiao-Long Yang*. Three new phenanthrenes with antimicrobial activities from the aerial parts of Juncus effuses. Fitoterapia, 2018, 130: 247-250.
[16] Xia Wu, Xue-Jiao Pang, Lu-Lin Xu, Qiong-Yin Zhang, Xin-Yu Long, Hai-Li Qin, Deng-Feng Yang*, Xiao-Long Yang*. Two new alkylated furan derivatives with antifungal and antibacterial activities from the plant endophytic fungus Emericella sp. XL029. Natural Product Research, 2018, 32: 2625-2631.
[17] Xue-Jiao Pang#, Shuai-Bing Zhang#, Hai-Li Chen, Wen-Ting Zhao, Deng-Feng Yang, Peng-Jie Xian, Lu-Lin Xu, Yan-Duo Tao*, Hai-Yan Fu*, Xiao-Long Yang*. Emericelactones A-D: Four novel polyketides produced by Emericella sp. XL 029, a fungus associated the leaves of Panax notoginseng. Tetrahedron Letters, 2018, 59: 4566-4570.
[18] Wei Zhao, Xiao-Wei Gong, Yuan-Xing Duan, Ji Yang, Xia Wu, Xian-Jun Jiang, Xiao-Hua Xu, Yong-Kuan Chen, Liu Yang*, Fei Wang*, Xiao-Long Yang*. Two new triterpenoids with antimicrobial activity from the leaves and twigs of Orophea yunnanensis. Natural Product Research, 2018, doi: 10.1080/14786419.2018.1481843.
[19] Dan Xu, Ming-He Luo, Feng-Lou Liu, Dong Wang, Xue-Jiao Pang, Ting Zhao, Lu-Lin Xu, Xia Wu, Ming-Yu Xia*, Xiao-Long Yang*. Cytochalasan and tyrosine-derived alkaloids from the marine sediment-derived fungus Westerdykella dispersa and their bioactivities. Scientific Reports, 2017, 7:11956-11964.
[20] Xia Wu, Li-Zhen Fang, Feng-Lou Liu, Xue-Jiao Pang, Hai-Li Qin, Ting Zhao, Lu-Lin Xu, Deng-Feng Yang, Xiao-Long Yang*. New prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus Emericella sp. XL029 and their anti-agricultural pathogenic fungal and antibacterial activities. RSC Advances, 2017, 7, 31115-31122.
[21] Dan Xu, Xue-Jiao Pang, Ting Zhao, Lu-Lin, Xiao-Long Yang*. New alkenylated tetrahydropyran derivatives from the marine sediment-derived fungus Westerdykella dispersa and their bioactivities. Fitoterapia, 2017, 122:45-51.
[22] Feng-Lou Liu, and Xiao-Long Yang*. Indole derivatives produced by the metagenome genes of the Escherichia coli-harboring marine sponge Discodermia calyx. Molecules, 2017, 22: 681.
