PRESENT ADDRESS:School of Pharmaceutical Sciences
South-Central University for Nationalities
182 Minzu Road
Wuhan 430074, CHINA
Tel: 0086-27-67842267
E-mail: jkliu@mail.kib.ac.cn; liujikai@mail.scuec.edu.cn
Team：
Dr. Feng Tao Associate Professor
Mr. Li Zheng-Hui Lecturer
Dr. Huang Rong Lecturer
Dr. Zheng Yong-Sheng Lecturer
Dr. Sun Huan Lecturer
Dr. Yuan Qin-Xia Post-doctor
Dr. Wang Wen-Xuan Post-doctor
Ms. Gan Xiao-Qing Technician
Mr. Peng Yun-Feng Technician
Graduate Students (Ph. D. or Master):
Chu Zhi-Yao, Chen Lin, Wang Zhen-Xiong, Duan Kai-Ting, Yu Xing, Yang Hui-Xiang, Li Wei, Pu Chao-Jun, Chen He-Ping, Zhao Zheng-Zhu, Zhang Shuai-Bing, Huang Ying, Tang Yan, Yao Jian-Neng
Education
Ph.D., Organic Chemistry, Lanzhou University, China, 1988
M.S., Medicinal Chemistry, China Pharmaceutical University, 1985
B.S., Pharmacy, Anhui University of Chinese Medicine, 1982
Professional Profile
2015-: Dean, Professor, School of Pharmaceutical Sciences, South-Central University for Nationalities
2005-2014: Deputy Director, Kunming Institute of Botany, Chinese Academy of Sciences
2005-present: Director, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
1997-present: Faculty Senior Scientist, State Key Laboratory of Phytochemistry and Plant Resources in West China
1997-present: Professor of Medicinal Chemistry, Natural Products Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
1996-1997: Senior Scientist, Bayer Pharma Research Center, Wuppertal, Germany
1995-1996: Professor of Chemistry, Sun Yat-Sen University (Zhongshan University), Guangzhou, China
1992-1994: Alexander von Humboldt Research Fellow, Saarland University, Saarbruecken, Germany
1992-1995: Associate Professor of Chemistry, Sun Yat-Sen University (Zhongshan University), Guangzhou, China
1988-1992: Lecturer, Sun Yat-Sen University (Zhongshan University), Guangzhou, China
Scientific and Professional Memberships
Editor-in-Chief: Natural Products and Bioprospecting, 2011-present
Associate Editor-in-Chief: Journal of Ginseng Research, 2014-present
Vice president: Botanical Society of Yunnan, 2010-present
Board Member: Botanical Society of China, 2008-present
Member of the Editorial Committee：
Journal of Chemical Ecology, 2007-2014;
Mycological Progress, 2011-present;
Journal of Asian Natural Products Research, 2010-present;
Chinese Journal of Natural Medicines, 2008-present;
Natural Product Research and Development, 2012-present;
Drug Discoveries & Therapeutics, 2007-present.
Z. Naturforsch. C 2016-
Corporate Founder: BioBioPha Inc.
Honorary Professor: Zhejiang University 2008; Central South University 2009
Scientific Advisor: State Key Laboratory of Applied Organic Chemistry, Lanzhou University; Institute of Chinese Medicine, The Chinese University of Hong Kong; Key Laboratory of Animal Model and Human Disease, Kunming Institute of Zoology, Chinese Academy of Sciences; Guangxi Normal University; Lanzhou Institute of Chemical Physics; Anhui University of Chinese Medicine.
Awards and Recognition
National Natural Science Prize, 2003, the Central People's Government of China
The Outstanding Scientific and Technological Workers in China, 2012
Tan Jiazhen Life Sciences Innovation Award, 2009
“973” Project Chief Scientist, 2009
Bayer-CAS Award, 2002
The National Science Fund for Distinguished Young Scholars, 2002
Hundred Talent Program of CAS, 1995
The Special Allowance of State Council of China, 1999
Research Interests
I am the author of about 300 publications, 2 monographs and the recipient of 10 patents. My research focuses on chemistry of natural products, especially isolation, structural elucidation, biosynthesis and total synthesis of biologically active compounds from fungi, new drug discovery based on natural bioactive compounds from fungi, chemical biology of natural products.
As the supervisor: 33 Ph. D. Students have been received their Ph. D. degrees successfully. They were very well trained, their research works were finished in my lab, and 5 of them have become the full professors, more half of them worked in industry as a key staff.
Symposia and Conferences (selected) in last 5 years
1.Plenary Lecture: IOCD International Conference on Functional Molecules in Nature, 2012-9-23~24, Nanjing
2.Plenary Lecture: Asian Mycological Congress 2009 & 11th International Marine and Freshwater Mycology Symposium, 2009-11-15~19, Taichung, Taiwan
3.Plenary Lecture: Annual Conference of Mycology Society of China, 2009-8-23~25, Beijing
4.Plenary Lecture: Annual Conference of Korea Mycology Society 2009, Seoul, Korea
5.Plenary Lecture: Annual Conference of Korea Mycology Society 2010-5-20, Korea
6.Invited Speaker: International Conference of the German Mycological Society, 2014-9-29~10-1, Mettlach, Germany
7.Invited Speaker: 28th International Symposium on the Chemistry of Natural Products and 8th International Conference on Biodiversity (ISCNP 28& ICOB8), 2014-10-19~24, Shanghai
8.Invited Speaker: The 16th Annual Meeting of China Association for Science and Technology (The International Forum on Conservation and Sustainable of Biological Resources in Southeast Asia), 2014-5, Yunnan
9.Invited Speaker: CCS 10th National Symposium on Natural Organic Chemistry, 2014-11-21~23, Guangzhou
10.Invited Speaker: International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010), Honolulu, Hawaii, December 15-20, 2010, USA.
11.Invited Speaker: ISCNP27 and ICOB7, 2011-7-10~15, Brisbane, Australia
12.Invited Speaker: 9th Annual Oxford International Symposium on the Science of Botanicals, 2010-4-12~15, Oxford, USA
13.Invited Speaker: International Conference on Traditional Chinese Medicine and Natural Medicine, 2009-10-17~18, Shanghai
14.Invited Speaker: Sino-German Symposium on Natural Products and Modern TCM Research, March 16-19, 2009, Kunming, China
15.Invited Speaker: Pure and Applied Chemistry International Conference, 2008-1-30~2-1, Bangkok, Thailand
Major Research Progress
In order to search for naturally occurring bioactive metabolites from fungiwe investigated the chemical constituents of more than 200 fungi in Southwest of China. A library contained more than 2000 including 700 novel compounds including terpenoids, phenolics and nitrogen-containing compounds from basidiomycetes and ascomycetes (Chem. Rev.2005, 105: 272; Chem. Rev. 2006, 106: 2209; Nat. Prod. Rep. 2010, 27: 1531; Nat. Prod. Rep. 2011, 28: 787) were established. Some of them showed very interesting pharmacological activities. Two drug candidates are evaluating for their potential as drugs before clinic.
Yunnan Sudden Deaths syndrome is responsible for more than 300 deaths in Yunnan Province, southwest China over the past 30 years. It has long been a mystery and a fascinating problem.We have identified the new toxic mushroom T. venenata, isolated two new toxic unusual amino acids from mushroom Trogia venenata guided by toxicity tests using mice, and detected directly new amino acid in a victim’s blood. Mice treated with both amino acids exhibited an increase in serum creatine kinase (CK) activity. These new toxins are the cause of ‘Yunnan Sudden Death’ syndrome, an important local epidemic of, as yet, undefined etiology (Angew. Chem. Int. Ed. 2013, 51: 2368;Science 2010, 329: 132; Science 2012, 335: 1293). We solve the problem. A campaign to warn people against eating the tiny mushroom with printed brochures has dramatically reduced the number of deaths, with none reported in 2010-2014! At least we have saved more than 80 people’s life.
Twelve people were hospitalized for severe weakness and muscle loss after eating the mushrooms, and three died. The poisoning the mushroom causes is referred to rhabdomyolysis (N. Engl. J. Med. 2001, 345: 798). We have identified the toxins found in a previously unknown poisonous European mushroom Tricholoma terreum. Fifteen novel triterpenoids were isolated from the fruiting bodies of the toxic mushroom T. terreum. Two abundant compounds in the mushroom displayed acute toxicity when administered orally in mice. Both compounds were found to increase serum creatine kinase levels in mice, indicating that T. terreum may be the cause of mushroom poisoning ultimately leading to rhabdomyolysis (Chem. Eur. J. 2014, 20: 1531).
Obesity represents a disorder of physiology whereby there is raised food intake resulting in increased deposition of fat within body tissues. There is an increasing incidence of obesity within the population.Obesity is associated with increased risk of diabetes, hypertension, cardiovascular disorders and renal diseases, which afflict 40% of these individuals. Clearly in both health and economic terms this represents a major treatment population. The lipase is one of the important target of anti-obesity drugs. Vibralactone, an unusual fused b-lactone type metabolite, was found to inhibit pancreatic lipase significantly. The structure and absolute configuration of vibralactone from the cultures of Basidiomycete Boreostereum vibrans was established by spectroscopic methods and computational methods. (Org. Lett. 2006, 8: 5749). Using vibralactone as original template the structure was optimized and more than 200 derivatives have been synthesized. We found a new compound with pancreatic lipase inhibitory activity with an IC50 in 14 nM which is 3000 times potent than vibralactone (applied patent). It has been as a drug candidate in evaluation. The unique biosynthetic pathway of vibralactone including several very interesting reactions which may involve unusual enzymes was elucidated (Angew. Chem. Int. Ed. 2013, 52: 2298).
We also discovered a series of new antitumor and anti-HIV agents from different fungi and clarified their mechanisms (Oncotarget 2014, on line; Cell Death Dis. 2013, 4: e804; Euro. J. Cancer 2011, 47: 316; Cancer Lett. 2007, 258: 199; Patent: US 7,659,308 B2; JP 4769726; Biochem. Biophys. Res. Comm. 2007, 355: 1091; Chemistry & Biodiverity 2008, 5: 447).
Selected Recent Publications:
1.Zhou ZY, Shi GQ, Fontaine R, Wei K, Feng T, Wang F, Wang GQ, Qu Y, Li ZH, Dong ZJ, Zhu HJ, Yang ZL, Zeng G*, and Liu JK*, Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China, Angew. Chem. Int. Ed. 2012, 51: 2368-2370
2.Yang YL, Zhou H, Du G, Feng KN, Feng T, Fu XL, Liu JK,* Zeng Y,* A Monooxygenase from Boreostereum vibrans Catalyzes Oxidative Decarboxylation in a Divergent Vibralactone Biosynthesis Pathway, Angew. Chem. Int. Ed., 2016, 55, 5463-5466.
3.Zhao LY, Wu MY, Xiao C, Yang L, Zhou LT, Gao N, Li Z, Chen J, Chen JC, Liu JK,* Qin HB,* Zhao JH,* Discovery of an intrinsic tenase complex inhibitor: Pure nonasaccharide from fucosylated glycosaminoglycan, Proc. Natl. Acad. Sci., USA, 2015, 112, 8284-8289.
4.Zhao PJ, Yang YL, Du LC, Liu JK, Zeng Y, Elucidating the Biosynthetic Pathway for Vibralactone: A Pancreatic Lipase Inhibitor wih a Fused Bicycle b-Lactone, Angew. Chem. Int. Ed. 2013, 52: 2298-2302
5.Yin X, Feng T, Shang JH, Zhao YL, Wang F, Li ZH, Dong ZJ, Luo XD, Liu JK*, Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum, Chem. Eur. J. 2014, 20, 7001-7009
6.Ji-Kai Liu, N-Containing Compounds of Macromycetes, Chem. Rev. 2005, 105: 2723-2744
7.Dong-Ze Liu, Fei Wang, Tou-Gen Liao, Jian-Guo Tang, Wolfgang Steglich, Hua-Jie Zhu, and Ji-Kai Liu*, A Lipase Inhibitor with an Unusual Fused beta-Lactone Produced by Cultures of the Basidiomycete Boreostereum vibrans. Org. Lett. 2006, 8: 5749-5752
8.Ding JH, Feng T, Li ZH, Yang XY, Guo H, Yin X, Wang GQ, Liu JK*, Trefolane A, a sesquiterpenoid with a new skeleton from cultures of the basidiomycete Tremella foliacea, Org. Lett. 2012, 14: 4976-4978
9.Yang XY, Feng T, Li ZH, Sheng Y, Yin X, Leng Y, Liu JK*, Conosilane A, an Unprecedented Sesquiterpene from the Culture of Basidiomycete Conocybe siliginea, Org. Lett. 2012, 14: 5382-5384
10.Yuan Gao, Gang-Qiang Wang, Kun Wei, Ping Hai, Fei Wang, and Ji-Kai Liu*，Isolation and biomimetic synthesis of (±)-guajadial B, a novel meroterpenoid from Psidium guajava, Org. Lett, 2012, 14: 5936-5939
11.Jiang MY, Feng T, and Liu JK*, N-containing compounds of macromycetes, Nat. Prod. Rep. 2011, 28, 787-808
12.Zhou ZY, and Liu JK*, Pigments of Fungi (macromycetes), Nat. Prod. Rep.2010, 27, 1531-1570
13.Ji-Kai Liu, Natural terphenyls: developments since 1877, Chem. Rev.2006, 106: 2209-2223
14.Ling Zhang, Rong-Hua Luo, Fei Wang, Meng-Yuan Jiang, Ze-Jun Dong, Liu-Meng Yang, Yong-Tang Zheng, and Ji-Kai Liu*, Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum, Org. Lett. 2010, 12: 152-155
15.Fei Wang, Yuan Gao, Ling Zhang, Bing Bai, Ya Nan Hu, Ze Jun Dong, Qi Wei Zhai, Hua Jie Zhu, and Ji Kai Liu*, A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity, Org. Lett, 2010,12: 3196-3199
16.Fei Wang, Yuan Gao, Ling Zhang, Ji-Kai Liu, Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro, Org. Lett. 2010, 12: 2354-2357
17.Guajadial: An Unusual Meroterpenoid from Guava Leaves Psidium guajava, Xiao-Long Yang, Kun-Lung Hsieh, and Ji-Kai Liu*, Org. Lett. 2007, 9: 513 5-5138
18.Total synthesis of (±)-Paeonilide, Chen-Ying Wang, Ji-Kai Liu, Yan-Hua Ji, Jing-Feng Zhao, Liang Li and Hong-Bin Zhang, Org. Lett.2006, 8: 2479-2481
19.Deng Q, Yu X, Xiao L, Hu Z, Luo X, Tao Y, Yang L, Liu X, Ding Z, Feng T, Tang Y, Weng X, Gao J, Yi W, Bode AM, Dong ZJ, Liu JK*, Cao Y*, Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-P13-K/Akt signaling pathway, Cell Death Dis. 2013, 4: e804
20.Wan Qiu Yang, Ji Kai Liu*, Hong Bin Zhang*, Total synthesis of pulverolide: revision of its structure, Tetrahedron Lett., 2010, 51: 4874-4876
21.Gang Qiang Wang, Kun Wei, Lin Zhang, Tao Feng, Fei Wang, Qiu An Wang and Ji Kai Liu*, One-step biomimetic synthesis of (±)-linderaspirone A and (±)-bi-linderone, Tetrahedron Lett., 2011, 52: 2719-2721
22.Tao Feng, Jia Su, Zhi Hui Ding, Yong Tang Zheng, Yan Li, Ying Leng, and Ji-Kai Liu*, Chemical constituents and their bioactivities of Tongling White Ginger (Zingiber officinale), J. Agric. Food Chem., 2011, 59: 11690-11695
23.Luo XJ, Li LL, Deng QP, Yu XF, Luo FJ, Xiao LB, Chen XY, Ye M, Liu JK*, Cao Y*, Grifolin, a potent antitumor natural product upregulates death-associated protein Kinase DAPK1 via p53 in nasopharyngeal carcinoma cells, Eur. J. Cancer 2011,47: 316-325
24.Yang XY, Feng T, Wang GQ, Ding JH, Li ZH, Li Y, He SH, Liu JK*, Chemical constituents from culture of the basidiomycete Trichaptum pargamenum, Phytochemistry 2014, 104: 89-94
25.Sun YS, Lv LX, Zhao Z, He X, You L, Liu JK*, Li YQ*, Cordycepol C induces Caspase-Independent Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells, Biol. Pharm. Bull. 2014, 37: 608-617
26.Hu DB, Li WX, Zhao ZZ, Feng T, Yin RH, Li ZH, Liu JK*, Zhu HJ*, Highly unsaturated pyranone derivatives from the Basidiomycete Junghunia nitida, Tetrahedron Lett. 2014, 55: 6530-6533
27.Chen ZM, Yang XY, Fan QY, Li ZH, Wei K, Chen HP, Feng T, Liu JK*, Three degraded steroids from cultures of the Basidiomycete Antrodiella albocinnamomea, Steroids 2014, 87: 21-25
28.Liu LY, Li ZH, Ding ZH, Dong ZJ, Li GT, Li Y, Liu JK*, Meroterpenoid Pigments from the Basidiomycete Albatrellus ovinus, J. Nat. Prod. 2013, 76: 79-84
29.Yin X, Feng T, Li ZH, Dong ZJ, Li Y, Liu JK*, Highly Oxygenated Meroterpenoids from Fruiting Bodies of the Mushroom Tricholoma terreum, J. Nat Prod. 2013, 76: 1365-1368
30.Ding JH, Feng T, Cui BK, Wei K, Li ZH, Liu JK*, Novel sesquiterpenoids from cultures of the basidiomycete Irpex lacteus, Tetrahedron Lett. 2013, 54: 2651-2654
31.Wang F, Mao MF, Wei GZ, Gao Y, Ren FC, Liu JK*, Hybridaphniphyllines A and B, Daphniphyllum alkaloid and iridoid hybrids suggestive of Diels-Alder cycloaddition in Daphniphyllum longeracemosum, Phytochemistry 2013, 95: 428-435
32.Wang F, Zhou DS, Wei GZ, Ren FC, Liu JK*, Chlorantholides A-F, euedsmane-type sesquiterpenes lactones from Chloranthus elatior, Phytochemistry 2012,77: 312-317
33.Meng Yuan Jiang, Yan Li, Fei Wang, Ji Kai Liu*, Isoprenylated cyclohexanoids from the basidiomycete Hexagonia speciosa, Phytochemistry, 2011, 72: 923-928
34.Ling Zhang, Rong Hua Luo, Fei Wang, Ze Jun Dong, Liu Meng Yang, Yong-Tang Zheng, Ji-Kai Liu*, Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals, Phytochemistry 2010, 71: 1879-1883
35.Dong Ze Liu, Ze Jun Dong, Fang Wang, Ji Kai Liu*, Two novel norsesquiterpene peroxides from basidiomycete Steccherinum ochraceum, Tetrahedron Lett. 2010, 51: 3152-3153
36.Ying Cheng Zhu, Gang Wang, Xiao Long Yang, Du Qiang Luo, Qin-Chang Zhu, Tao Peng, Ji-Kai Liu*, Agrocybone, a novel bis-sesquiterpene with a spirodienone structure from basidiomycete Agrocybe salicacola, Tetrahedron Lett. 2010, 51: 3443-3445
37.Meng-Yuan Jiang, Yan Li, Fei Wang, Ji-Kai Liu*, Isoprenylated cyclohexanoids from the basidiomycete Hexagonia speciosa, Phytochemistry, 2011, 72, 923-928
38.Zhang L, Shen Y, Wang F, Leng Y, Liu JK, Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11β-hydroxysteroid dehydrogenases, Phytochemistry2010,71, 100-103
39.Meng Yuan Jiang, Ling Zhang, Rong Liu, Ze Jun Dong, and Ji Kai Liu*, Speciosins A-K, oxygenated cyclohexanoids from the basidiomycete Hexagonia speciosa, J. Nat. Prod. 2009, 72, 1405-1409
40.Zhang L, Shen Y, Zhu HJ, Wang F, Leng Y, Liu JK, Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11-beta-hydroxysteroid dehydrogenases inhibitory activity, J. Antibiot. 2009, 62, 239-242
41.Hong-Jun Shao, Xiang-Dong Qin, Ze-Jun Dong, Hong-Bin Zhang, and Ji-Kai Liu*,Induced daldinins A, B, C with a new skeleton from cultures of the Ascomycete Daldinia concentric,.J. Antibiot. 2008, 61: 115-119
42.Zhong-Yu Zhou, Jian-Guo Tang, Fei Wang, Ze-Jun Dong, and Ji-Kai Liu*,Sesquiterpenes and Aliphatic Diketones from Cultures of the Basidiomycete Conocybe siliginea, J. Nat. Prod., 2008, 71: 1423-1426
43.Dong-Ze Liu, Fei Wang, Ji-Kai Liu*, Sesquiterpenes from the Cultures of the Basidiomycete Conocybe siliginea, J. Nat. Prod. 2007, 70: 1503-1506
44.Flazinamide, a Novel β–Carboline Compound with anti-HIV Actions, Yun-Hua Wang, Jian-Guo Tang, Rui-Rui Wang, Liu-Meng Yang, Ze-Jun Dong, Li Du, Xu Shen, Ji-Kai Liu*, Yong-Tang Zheng*, Biochem. Biophys. Res. Comm., 2007, 355: 1091-1095
45.Xiang-Dong Qin, Ze-Jun Dong, Ji-Kai Liu*, Liu-Meng Yang, Rui-Rui Wang, Yong-Tang Zheng, Yang Lu, Yun-Shan Wu and Qi-Tai Zheng, Concentricolide, an Anti-HIV Agent from the Ascomycete Daldinia concentrica, Helv. Chim. Acta2006, 89: 127-133
46.Ling Zhang, Fei Wang, Ze-Jun Dong, Wolfgang Steglich and Ji-Kai Liu*, A New Butenolide-Type Fungal Pigment from the Mushroom Pulveroboletus ravenelii, Heterocycles2006, 68: 1455-1458
47.Li-Zhen Fang, Chen Qing, Hong-Jun Shao, Yi-Dong Yang, Ze-Jun Dong, Fei Wang, Wei Zhao, Wan-Qiu Yang, and Ji-Kai Liu*, Hypocrellin D, a Cytotoxic Fungal Pigment from Fruiting Bodies of the Ascomycete Shiraia bambusicola, J. Antibiot.2006, 59: 351-354
48.Du-Qiang Luo, Yuan Gao, Jin-Ming Gao, Fei Wang, Xiao-Long Yang and Ji-Kai Liu*, Humulane-Type Sesquiterpenoids from the Mushroom Lactarius mitissimus, J. Nat. Prod.2006, 69: 1354-1357
49.Mao Ye, Ji-Kai Liu*, Zhong-Xin Lu, Yan Zhao, Su-Fang Liu, Li-Li Li, Ming Tan, Xin-Xian Weng, Wei Li, Ya Cao*, Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro, FEBS Letters 2005, 579: 3437-3443
50.F.Wang, J.K.Liu*, Two new steryl esters from the basidiomycete Tricholomopsis rutilans, Steroids2005, 70: 127-130
51.Du-Qiang Luo, Hong Wang, Xuan Tian, Hong-Jun Shao and Ji-Kai Liu*, Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus, Pest Manag. Sci. 2005, 61: 85-90
52.Xing-Na Wang, Ren-Xiang Tan, Ji-Kai Liu*, Xylactam, a New Nitrogen-containing Compound from the Fruiting Bodies of Ascomycete Xylaria euglossa, J. Antibiot.2005, 58: 268-270
53.Du-Qiang Luo, Fei Wang, Xiao-Ying Bian, Ji-Kai Liu*, Rufuslactone, a New Antifungal Sesquiterpene from the Fruiting Bodies of the Basidiomycete Lactarius rufus, J. Antibiot. 2005, 58: 456-459
54.Fei Wang, Du-Qiang Luo, Ji-Kai Liu*,Aurovertin E, a New Polyene Pyrone from the Basidiomycete Albatrellus confluens, J. Antibiot. 2005, 58: 412-415
55.Hong-Jun SHAO, Chen QING, Fei WANG, Yan-Li ZHANG, Du-Qiang LUO, and Ji-Kai LIU*, A New Cytotoxic Lanostane Triterpenoid from the Basidiomycete Hebeloma versipelle, J. Antibiot. 2005, 58: 828-831
56.Jian-Wen Tan, Ji-Bing Xu, Ze-Jun Dong, and Ji-Kai Liu*, Nigricanin, the First Ellagic Acid Derived Metabolite from the Basidiomycete Russula Nigricans, Helv. Chim. Acta 2004, 87: 1025-1028
57.Du-Qiang Luo, Xing Zhang, Xuan Tian, and Ji-Kai Liu*, Insecticidal Compounds from Tripterygium wilfordii Active against Mythimna separate, Z. Naturforsch. 2004, 59c: 421-426
58.Ji-Kai Liu*, Lin Hu, Ze-Jun Dong, and Qun Hu, DPPH Radical Scavenging Activity of Ten Natural p-Terphenyl Derivatives Obtained fron Three Edible Mushrooms Indigenous to China, Chemistry & Biodiversity2004, 1: 601-605
59.Xiang-Dong Qin, Ji-Kai Liu*, Natural Aromatic Steroids as Potential Molecular Fossils from the Fruiting Bodies of the Ascomycete Daldinia concentrica, J. Nat. Prod. 2004, 67: 2133-2135
60.,Jin-Ming Gao, An-Ling Zhang, Hui Chen, Ji-Kai Liu*, Molecular species of ceramides from the ascomycete truffle Tuber indicumChem. Phys. Lipids2004, 131: 205-213
61.Chen Qing, Ming-Hua Liu, Wei-Ming Yang, Yan-Li Zhang, Lei Wang, Ji-Kai Liu, Effects of Albaconol from the Basidiomycete Albatrellus confluens on DNA Topoisomerase II-Mediated DNA Cleavage and Relaxation, Planta Medica 2004, 70: 792-796
62.Jianwen Tan, Pawel Bednarek, Jikai Liu, Bernd Schneider, Aleš Svatoš, Universally occurring phenylpropanoid and species-specific indolic metabolites in infected and uninfected Arbidopsis thaliana roots and leaves, Phytochemistry 2004, 65: 691-699
63.Qian Wang, Zhi-Hui Ding, Ji-Kai Liu, and Yong-Tang Zheng, Xanthohumol,a novel ant-HIV-1 agent purified from hops humulus lupulus, Antiviral Rescearch 2004, 64: 189-194
