Prof. Dr. Xinzhou Yang
School of Pharmaceutical Science, South-Central University for Nationalities,Wuhan 430074, Wuhan 430074, China
Tel.: 027-67841196 (office); E-mail: xzyang@mail.scuec.edu.cn
Research Expertise
●Isolation and structure elucidation of bioactive natural products from TCMs and TCEMs
●Chemical biology using a natural product library on a cell-based GLUT4 translocation assay with stable L6 cells expressing pIRAP-mOrange cDNAsto discover potential antidiabetic agents
●Identification of small molecule enzyme inhibitors using mass spectrometry
Education
● Tongji Medical University, Wuhan, China (1995.9-1999.7)
Bachelor of Science (1999.7)
Majors in Pharmacy
● Huazhong University of Science and Technology, Wuhan, China (1999.9-2002.7)
Master of Medicine (2002.7)
Majors in Pharmaceutical chemistry
● Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (2002.9-2005.7)
Doctor of Philosophy (2005.7)
Majors in Organic Chemistry
Employment History
● Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (2005.7-2007.9)
Assistant Research Fellow
●Basel University, Basel, Switzerland (2007.9-2009.1)
Postdoctor Fellow
● Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Australia (2009.1-2010.12)
Research Fellow
● School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China (2010.12-present)
Associate Professor, Professor
Research Profile
● Overview
My research expertise is to combine the massive chemical diversity and biological relevance of natural products with the power of high sensitive screening to expedite the search for biologically active compounds that could form the basis for new therapeutic agents. My research group also investigates traditional Chinese Medicines (TCMs) and traditional Chinese Ethnic Medicines (TCEMs) where we look at (1) bioactive natural products from the herbal medicines (2) the relationship of the biological activities of different structural classes (3) the synergistic effect of the different components of the herbal medicines.
My research platform includes (1) primary bioassay screenings of natural product library; (2) activity confirmation by retest and secondary assays; (3) the active fractions/crude extracts are analysed by LC-MS or off-line LC-NMR for potential molecular ions and dereplication by search in the databases; (4) large scale isolation by bioassay-guided or mass-guided protocols, and structural elucidation of pure compounds by NMR and MS; (5) activity evaluation of the pure compounds and lead identification; (6) validating the potential antidiabetic or antitumor effects of pure natural products in vitro and in vivo; (7) Elucidating the potential mechanism of active natural products.
Projects
1. Chinese National Natural Science Foundation grant (No. 81774000, 2018-2021, Principal Investigator)
2. Chinese National Natural Science Foundation grant (No. 81573561, 2016-2019, Principal Investigator)
3. Chinese National Natural Science Foundation grant (No. 81102798, 2012-2014, Principal Investigator)
4.3551 Talent Program of Donghu National High-Tech Zone of Wuhan City (BX219, 2014-2017, Principal Investigator)
5. Open Foundation from the State Key Laboratory of Drug Research in Shanghai Institute of Material Medica (SIMM1403KF-07, 2014-2015, Principal Investigator)
6. Wuhan Youth Chenguang Program of Science and Technology (2013070104010028, 2013-2014, Principal Investigator)
7. Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China (BZY12006, Principal Investigator)
8. Talented Faculty Foundation of South-Central University for Nationalities (YZ211002, Principal Investigator)
9. Fundamental Research Funds for the Central Universities (3212014CZW14051, 2014-2015, Principal Investigator)
10. Chinese National Project of Twelfth Five-Year Plan for Science & Technology Support (2012BAI27B06, 2011-2015)
11.Natural Science Foundation of Qinghai Province (2012-Z-904)
12. Natural Science Foundation of Qinghai Province (2016-ZJ-908)
Recent Publications
1. Sijian Zheng1, Shihao Deng1, Mi Huang, Ping Zhao, Yun Huang, Xinhua Ma, Yanzhang Wen, Qiang Wang*, Xinzhou Yang*. Anti-diabetic activity of polyphenol-rich extract from Phellinus igniarius in KK-Ay mice with spontaneous type 2 diabetes mellitus. Food & Function, 2018, 9: 614-623. (1co-first authors, IF3.25)
2. Mingrui Xiong1, Yun Huang1, Yajing Liu, Mi Huang, Guanjun Song, Qian Ming, Xinhua Ma, Jie Yang, Shihao Deng, Yanzhang Wen, Jinhua Shen, Qing-Hua Liu, Ping Zhao*, Xinzhou Yang*. Antidiabetic activity of ergosterol from Pleurotus ostreatus in KK-Ay mice with spontaneous type 2 diabetes mellitus. Molecular Nutrition & Food Research, 2018, DOI: 10.1002/mnfr.201700444. (1co-first authors, Top, IF4.32)
3. Jie Yang1, Hao Chen1, Shihao Deng, Mi Huang, Xinhua Ma, Ping Song, Jingwen Du, Yun Huang, Yanzhang Wen, Yongshen Ren*, Xinzhou Yang*. Inhibitory effect of kurarinone on growth of human non-small cell lung cancer: an experimental study both in vitro and in vivo studies. Frontiers in Pharmacology, 2018, https://doi.org/10.3389/fphar.2018.00252. (1co-first authors, IF4.40)
4. Hao Chen1, Bei Zhou1, Jie Yang, Xinhua Ma, Shihao Deng, Yun Huang, Yanzhang Wen, Jingquan Yuan*, Xinzhou Yang*. Frontiers in Pharmacology, 2018, accepted. (1co-first authors, IF4.40)
5. Dan Lv, Jie Yang, Chan Xu, Mi Huang, Sijian Zheng, Xinhua Ma, Qiang Wang*, Xinzhou Yang*. Essential oil from Euphorbia esula inhibits proliferation and induces apoptosis in HepG2 cells via mitochondrial reactive oxygen species. Brazilian Journal of Pharmaceutical Sciences, 2018, accepted.
6. Xinzhou Yang1, Mi Huang1, Jinyan Cai, Dan Lv, Jingnan Lv, Sijian Zheng, Xinhua Ma, Ping Zhao*, Qiang Wang*. Chemical profiling of anti-hepatocellular carcinoma constituents from Caragana tangutica Maxim. by off-line semi-preparative HPLC-NMR. Nat. Prod. Res., 2017, 31 (10): 1150-1155. (1co-first authors, IF1.83)
7. Xinhua Ma, Jie Yang, Shihao Deng, Mi Huang, Sijian Zheng, Shicheng Xu, Jinyan Cai, Xinzhou Yang* & Honglian Ai*. Two new megastigmanes from Chinese traditional medicinal plant Sedum sarmentosum. Nat. Prod. Res., 2017, 31(13):1473-1477. (IF1.83)
8. Xinzhou Yang1, Shihao Deng1, Mi Huang, Jialin Wang, Li Chen, Mingrui Xiong, Jie Yang, Sijian Zheng, Xinhua Ma, Ping Zhao*, Yunjiang Feng*. Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities. Bioorg. Med. Chem. Lett., 2017, 27 (6): 1463-1466. (1co-first authors, IF2.45)
9. Dan Lv1, Kai-wen Guo1, Chan Xu, Mi Huang, Si-jian Zheng, Xin-hua Ma, Li-hong Pan, Qiang Wang*, Xin-zhou Yang*. Essential oil from Siegesbeckia pubescens induces apoptosis through the mitochondrial pathway in human HepG2 cells. J. Huazhong Univ. Sci. Technol. Med. Sci. 2017, 37 (1): 87-92. (1Co-first author, IF0.96)
10. Xinzhou Yang1, Mi Huang1, Jie Yang, Jialin Wang, Sijian Zheng, Xinhua Ma, Jinyan Cai, Shihao Deng, Gunagwen Shu*, Guangzhong Yang*. Activity of isoliensinine in improving the symptoms of type 2 diabetic mice via activation of AMP-activated kinase and regulation of PPARγ. J. Agric. Food Chem., 2017, 65 (33): 7168-7178. (1Co-first author, IF3.15)
11. Jialin Wang1, Mi Huang1, Jie Yang, Xinhua Ma, Sijian Zheng, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*, Ping Zhao*. Anti-diabetic activity of stigmasterol from soybean oil by targeting GLUT4 glucose transporter. Food & Nutrition Research, 2017, 61 (1): 1364117. (1Co-first author, IF 2.04)
12. Li Chen1, Sijian Zheng1, Mi Huang1, Xinhua Ma, Jie Yang, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*. β-Ecdysterone from Cyanotis arachnoidea exerts hypoglycemic effects through activating IRS-1/Akt/GLUT4 and IRS-1/Akt/GLUT2 signal pathways in KK-Ay mice. Journal of Functional Foods, 2017, 39: 123-132. (1Co-first author, IF3.144)
13. Xinhua Ma1, Jie Yang1, Christopher L. Brownb, Chao Wang, Shihao Deng, Ruifang Ke, Shicheng Xu, Mi Huang, Xinzhou Yang* ,Yunjiang Feng*. Cytotoxic neolignans from Daphniphyllum macropodum Miq. RSC Advances, 2017, 7: 52970-52976. (1Co-first author, IF3.11)
14. Yan Hu*, Hao Chen, Ma Zuo, Xinzhou Yang, Dan Zhao, Suying Zeng, Xincai Xiao*. Natural material-decorated mesoporous silica nanoparticles container for multifunctional membrane-controlled targeted drug delivery. International Journal of Nanomedicine, 2017, 12: 8411-8426. (IF4.47)
15. Jie Yang1, Chan Xu1, Hao Chen, Mi Huang, Xinhua Ma, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*, Ping Song*. In vitro and in vivo antitumor effects of the diterpene enriching extract from Taxodium ascendens through the mitochondrial-dependent apoptosis pathway. Biomedicine & Pharmacotherapy, 2017, 96: 1199-1208. (1Co-first author, IF2.76)
16. Qi Zhou1, Xinzhou Yang1, Mingrui Xiong, Xiaolan Xu, Li Zhen, Weiwei Chen, Yan Wang, Jinhua Shen, Ping Zhao*, Qing-Hua Liu*. Chloroquine increases glucose uptake via enhancing GLUT4 translocation and fusion with the plasma membrane in L6 cells. Cell. Physiol. Biochem. 2016, 38: 2030-2040. (1co-first author, IF5.10)
17. Xinzhou Yang*, Mi Huang, Sijian Zheng, Xinhua Ma, Dingrong Wan, Yunjiang Feng*. Liquid chromatography with mass spectrometry and NMR spectroscopy based discovery of cytotoxic principles from Daphne tangutica Maxim. J. Sep. Sci., 2006, 39 (11): 2179-2187. (IF2.56)
18. Mi Huang, Ping Zhao, Mingrui Xiong, Qi Zhou, Sijian Zheng, Xinhua Ma ,Chan Xu, Jing Yang, Xinzhou Yang*, Tong-Cun Zhang*. Antidiabetic activity of perylenequinonoid-rich extract from Shiraia bambusicola in KK-Ay mice with spontaneous type 2 diabetes mellitus. J. Ethnopharmacol., 2016, 191: 71-81. (IF2.98)
19. Karren D. Beattie, Nicola Ellwood, Rohitesh Kumar, Xinzhou Yang, Peter C. Healy, Vanida Choomuenwai, Ronald J. Quinn, Alysha G. Elliott, Johnny X. Huang, Jessica L. Chitty, James A. Fraser, Matthew A. Cooper, Rohan A. Davis*. Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D–F. Phytochemistry, 2016, 124: 79-85. (IF3.21)
20. Guangwen Shu, Lang Zhang, Shanqing Jiang, Zhuo Cheng, Guan Wang, Xu Huang, Xinzhou Yang*. Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction. Oncotarget, 2016, doi: 10.18632/oncotarget.9603.
21. Mi Huang, Shihao Deng, Qianqian Han, Ping Zhao, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, XinzhouYang*. Hypoglycemic activity and the potential mechanism of the flavonoid rich extract from Sophora tonkinensis Gagnep. in KK-Ay mice. Frontiers in Pharmacol., 2016, doi: 10.3389/fphar.2016.00288. (IF4.40)
22. Chao Wang, Xinzhou Yang, George Mellick*, Yunjiang Feng*. Meet the challenge: probing Parkinson’s disease biology by integrated multidisciplinary methodology. ACS Chemical Neuroscience, 2016, 7(12): 1628–1634. (IF3.88)
23. Xinzhou Yang1, Jing Yang1, Chan Xu, Mi Huang, Qi Zhou, Jingnan Lv, Xinhua Ma, Changqiang Ke, Yang Ye, Guangwen Shu*, Ping Zhao*. Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in Type 2 diabetic KK-Ay mice. J. Ethnopharmacol., 2015, 171: 161-170. (1co-first author, IF2.98)
24. Ping Song1, Qiang Wang1, Jingnan Lv, Chan Xu, Qinxiong Lin, Xinhua Ma, Mi Huang, Xinzhou Yang*. HPLC-based activity profiling of anti-Hepatocellular carcinoma constituents from the tibetan medicine, Caragana tibetica. J. Huazhong Univ. Sci. Tech. Med. Sci., 2015, 35 (3): 450-455. (1Co-first author, IF0.96)
25. Guangwen Shu, Ling Yue, Wenhao Zhao, Chan Xu, Jing Yang, Shaobing Wang, Xinzhou Yang*. Isoliensinine, a bioactive alkaloid derived from embryos of Nelumbo nucifera, induces hepatocellular carcinoma cell apoptosis through suppression of NF-κB signaling. J. Agric. Food Chem., 2015, 63 (40): 8793-8803. (IF3.15)
26. Chao Wang, Jing Yang, Ping Zhao, Qi Zhou, Zhinan Mei, Guangzhong Yang, Xinzhou Yang*, Yunjiang Feng*. Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities. Bioorg. Med. Chem. Lett., 2014, 24 (14): 3096-3099. (IF2.54)
27. Xinzhou Yang1, Chao Wang1, Dingrong Wan, Qinxiong Lin, Guangzhong Yang, Zhinan Mei*, Yunjiang Feng*. Antimicrobial sesquiterpenes from the Chinese medicinal plant, Chloranthus angustifolius. Tetrahedron Letters, 2014, 55 (41): 5632-5634. (IF2.19)
28. Guangwen Shu, Jing Yang, Chan Xu, Zhinnan Mei, Xinzhou Yang*. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicology and Applied Pharmacology, 2014, 281 (2):157-65. (IF3.79)
29. Jing Yang, Ping Zhao, Qi Zhou, Chao Wang, Dingrong Wan, Guangwen Shu, Zhinan Mei, Xinzhou Yang*. Antidiabetic effect of methanolic extract from Berberis julianae Schneid. via activation of AMP activated protein kinase in type 2 diabetic mice. Evidence-Based Complementary and Alternative Medicine, 2014, 106206, http://dx.doi.org/10.1155/2014/106206. (IF1.74)
30. Chao Wang, Jing Yang, Zhinan Mei, Xinzhou Yang*. Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans Hance. Pharmacog. Mag., 2014, 10 (37), 73-76. (IF1.07)
31. Jing Yang, Xinzhou Yang*, Chao Wang, Qinxiong Lin, Zhinan Mei, Ping Zhao*. Sodium-glucose linked transporter 2 inhibitors from Sophora flavescens. Med. Chem. Res., 2015, 24, 1265-1271. (IF1.28)
32. Rohan Davis, Karren Beattie, Min Xu, Xinzhou Yang, Sheng Yin, Harish Hola, Peter Healy, Melissa Sykes, Todd Shelper, Vicky Avery, Mikael Elofsson, Charlotta Sundin, Ronald J Quinn*. Solving the supply of resveratrol tetramers from Papua New Guinean rainforest Anisoptera species (Dipterocarpaceae) that inhibit bacterial type III secretion systems. J. Nat. Prod., 2014, 77 (12): 2633-2640. (IF3.28)
33. Jingquan Yuan, Tong Li, Zhinan Mei, Jiaomei Jiang, Yaqin Zhou, Zhigang Yan, Jianhua Miao, Xinzhou Yang*, Xiaojun Ma*. Chemistry and Biological Activities of Huperzia serrata. Current Opinion Complement Alternative Medicine, 2014, 1 (2): 1-11.
34. Ping Song, Jingquan Yuan, Xinzhou Yang*. Cytotoxic constituents from Psoralea corylifolia. J. Asian Nat. Prod. Res., 2013, 15 (6): 624-630. (IF1.07)
35. Lvyi Chen*, Lan Zhou, Shuwei Ma, Ling Zhao, Xinzhou Yang*. Attenuation of Gouty Arthritis by Emodinol in Monosodium Urate Crystal-Treated Mice. Planta Med., 2013, 79 (8): 634-638. (IF2.34)
36. Shasha Mo, Hui Xiong, Guangwen Shu, Xinzhou Yang, Jianxia Wang, Congyi Zheng, Wei Xiong, Zhinan Mei*. Phaseoloideside E, a novel natural triterpenoid saponin identified from Entada phaseoloides, induces apoptosis in Ec-109 esophageal cancer cells through reactive oxygen species generation. J. Pharmacol. Sci., 2013, 122 (3): 163-175.
37. Xinzhou Yang, Chunping Tang, Ping Zhao, Guangwen Shu*, Zhinan Mei*. Antimicrobial Constituents from Bletilla ochracea Schltr. Planta Med., 2012, 78, 606-610. (IF2.34)
38. Jinfu Wan, Jinquan Yuan, Zhinan Mei, Xinzhou Yang*. Phenolic Glycosides from Boschniakia himalaica. Chin. Chem. Lett., 2012, 23: 579-582. (IF1.93)
39. Xinzhou Yang, Yunjiang Feng, Sandra Duffy, Vicky M Avery, David Camp, Ronald J Quinn*. A new quinoline epoxide from the Australian plant Drummondita calida. Planta Med., 2011, 77: 1644-1647. (IF2.34)
40. Xinzhou Yang, Igor Baburin, Inken Plitzko, Steffen Hering, Matthias Hamburger*. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root). Mol. Diversity, 2011, 15: 361-372. (IF1.76)
41. Xinzhou Yang, Rohan A. Davis, Malcolm S. Buchanan, Sandra Duffy, Vicky M. Avery, David Camp, Ronald J. Quinn*. Antimalaria bromotyrosine derivatives from the Australian marine sponge Hyattella sp. J. Nat. Prod., 2010, 73: 985-987. (IF3.28)
42. Xinzhou Yang, Peter Künze, Inken Plizolo, Olivier Potterat, Matthias Hamburger*. Bicyclononane aldehydes and antiproliferative constituents from Amomum tsao-ko. Planta Med., 2009, 75: 543-546. (IF2.34)
43. Xinzhou Yang, Jianyu Zhu, Chunping Tang, Changqiang Ke, Ge Lin, Tin-Yan Cheng, John A. Rudd, Yang Ye*. Alkaloids from roots of Stemona sessilifolia and their antitussive activities. Planta Med., 2009, 75: 174-177. (IF2.34)
44. Li-Gen Lin1, Xin-Zhou Yang1, Chun-Ping Tang, Chang-Qiang Ke, Ji-Bao Zhang, Yang Ye*. Antibacterial stilbenoids from Stemona tuberosa. Phytochemistry, 2008, 69, 457-463. (1co-first author, IF3.23)
45. Jing-Quan Yuan, Xin-Zhou Yang, Jian-Hua Miao, Chun-Ping Tang, Chang-Qiang Ke, Ji-Bao Zhang, Xiao-Jun Ma*, Yang Ye*. New Antifungal triterpene glucosides from the roots of Rosa laevigata Michx. Molecules, 2008, 13: 2229-2237. (IF2.86)
46. Xinzhou Yang, Tobias A. M. Gulder, Matthias Reichert, Chunping Tang, Changqiang Ke, Yang Ye*, Gerhard Bringmann*. Parvistemins A-D, a new type of dimeric phenylethyl benzoquinones from Stemona parviflora Wright. Tetrahedron, 2007, 63: 4688-4694. (IF2.65)
47. Xin-Zhou Yang, Li-Gen Lin, Chun-Ping Tang, Yong-Qiang Liu, Yang Ye*. Non-alkaloid constituents from Stemona japonica. Helv. Chim. Acta, 2007, 90: 318-325.
48. Xin-zhou Yang, Chun-ping Tang, Chang-qiang Ke and Yang Ye*. Stilbenoids from Stemona sessilifolia. J. Asian Nat. Prod. Res., 2007, 9 (3): 261-266.
49. Xin-zhou Yang, Yi-ping Yang, Chun-ping Tang, Chang-qiang Ke and Yang Ye*. Rapid Identification of bibenzyls of Stemona sessilifolia by hyphenated LC-UV-NMR and LC-MS methods. Chem. J. Chin. Univ., 2007, 23: 48-51.
50. Xin-zhou Yang, Chun-ping Tang and Yang Ye*. Stilbenoids from Stemona japonica. J. Asian Nat. Prod. Res., 2006, 8 (1-2): 47-53.
