School of Pharmaceutical Science, South-Central University for Nationalities
Nationality: People’s Republic of China Health: Excellent
E-mail address: xiangmeixian99@163.com;
Education
Ph.D. 2011, pharmaceutical engineering, Huazhong University of Science and Technology , P.R. China
M.S. 2004, Traditional Chinese Medicine, Hubei University of Chinese Medicine, P.R. China
B.S. 1997,Traditional Chinese Medicine, Hubei University of Chinese Medicine, P.R. China
Working experience
2004.7-2011.5 lecturer, College of Pharmacy, South-Central University for Nationalities, Wuhan.
2011.6-present: Associate Professor, College of Pharmacy, South-Central University for Nationalities, Wuhan.
Research interests
Natural product chemistry, Anti-cancer Pharmacology.
Projects
1.Study on active ingredients and mechanism of promoting fracture healing about Polygonum amplexicaule var. Sinese. the National Fund of Natural Science 2012.1-2015.12.
2. Research about Biyuanling Granules, the Natural Science Foundation of Hubei Province. 2015.1-2017.12.
3.Study mechanism of promoting fracture healing on secondary metabolities from Polygonum amplexicaule var. Sinense. The Natural Science of Hubei province. 2011.3-2012.10.
4.Research about Xuesanqi capsules, Key project of science and technology of wuhan Municipal Government. 2012.7-2014.7.
5. Research on the preparation of Biyuanling Granules, The Natural Science of Wuhan Municipality. 2016.3-2018.12
Publications
1.Meixian Xiang , Hanwen Su, Guang wen Shu , Ding rong Wan, Feng He , Loaec M,i Yali Ding,Jun Li, Dovat Sunny, Guangzhong Yang , Chunhua Song. Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer. Oncotarget. 2016, 7(14):18521-30
2. Meixian Xiang, Hanwen Su ,Yajing Hu, Yun Hu, Tianming Yang, and Gu angwen Shu, Chemical composition of total flavonoids from Salvia Chinensia Benth and their pro-apoptotic effect on Salvia hepatoce -llular carcinoma cells: potential roles of suppressing cellular NF-κB signaling. Food and chemical toxicology. 2013 Sep 12;62C:420-426. doi: 10.1016/j.fct.2013.09.008.
3.Mei-xian Xiang, Han-wen Su, Zong-guo Hong, Guang-wen Shu. Chemical composition of total flavonoids from Polygonum amplexicaule D.Don var.sinensr Forb. And their pro-apototic effect on hepatocellular carcinoma cells: potential roles of suppressing signal transducer and activator of transcription 3 signaling. Food and Chemical Toxicology, 2015(80): 62-71.
4.Meixian Xiang, Hanwen Su, Yun Hu, Yajing Hu,Tianming Yang , Shu G. Chemical composition of total flavonoids from Salvia chinensia Benth and their pro-apoptotic effect on hepatocellular carcinoma cells: potential roles of suppressing cellular NF-κB signaling. Food Chem Toxicol. 2013 Dec;62:420-6. doi: 10.1016/j.fct.2013.09.008. Epub 2013 Sep 12.
5. Guangwen Shu, Tianming Yang, Chaoyuan Wang, Hanwen Su,
Meixian Xiang* Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: involvement of NF-κB signaling activation in CD4 + T cells.Toxicology and Applied Pharmacology. 2013 Jun 15;269(3):270-9.
6.Mei-Xian Xiang, Zong Xu, Han-Wen Su, Jinyue Hu, Yun-Jun Yan. Emodin-8-O-β-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells. Molecules, 2011, 16: 728-737.
7.Mei-xian Xiang, Li Xu, Yun Liu, Yun-jun Yan, Jin-yue Hu and Han-wen Su. In vitro evaluation of the effects of Polygonum orientale L. on proliferation and differentiation of osteoblastic MC3T3-E1 cell. Journal of Medicinal Plants Research, 2011, 5(2): 231-236.
8.Mei-xian Xiang, Hanwen Su, Jinyue Hu, Yunjun Yan. Isolation, identification and determination of methyl caffeate, ethyl caffeate and other phenolic compounds from Polygonum amplexicaule D. Don var. sinense Forb. Journal of Medicinal Plants Research, 2011, 5 (9): 1685-1691
9.Mei-Xian Xiang, Han-Wen Su, Jin-yue Hu, Yun-Jun Yan. Stimulative effects of Polygonum amplexicaule D. Don var. sinense Forb. (Polygonaceae) on osteoblastic MC3T3-E1 cells. Pharmacology Biology，2011, may 20.
10. Guang-wen Shu, Zong-guo Hong, Mei-xian Xiang*. Antitumor immunostimulatory activity of polysaccharides from Salvia chinensis Benth. Journal of Ethnopharmacology. 2015 (168): 237-247.
11.Xiaobing Chen1, Hanwen Su2, Huanxiang Liu2, Xian Yin1, Feng He1, Yongshen Ren1, Meixian Xiang1, 3**Anti-inflammatory, and protective effects of Bi-yuan-ling Granules on the acute lung injury in mice.J Huazhong Univ Sci Technolog Med Sci. 2016, 36(3): 456-462.
12. Wang H, Song C, Ding Y, Pan X, Ge Z, Tan BH, Gowda C, Sachdev M, Muthusami S, Ouyang H, Lai L, Francis OL, Morris CL, Abdel-Azim H, Dorsam G, Xiang M, Payne KJ, Dovat S.
Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.J Biol Chem. 2016 Feb 19; 291 (8): 4004-18. doi: 10.1074/jbc.M115.679332. Epub 2015 Dec 10.
13. Xiaobing Chen, Hanwen Su, Huanxiang Liu, Xian Yin, Feng He,Yongshen Ren, Meixian Xiang**.Anti-inflammatory, and protective effects of Bi-yuan-ling Granules on the acute lung injury in mice [J]. J Huazhong Univ Sci Technolog Med Sci. 2016, 36(3): 456-462.
