Lvyi Chen, Ph. D.
Associate Professor
School of Pharmacy
South-Central University for Nationalities, Wuhan, China
E-mail: clyhappy05@163.com
Address:
No. 182 Minyuan Road, Hongshan District, Wuhan, China
Phone (work): +86 27 67841196
Education
A.V. 2017-2019
Ph.D. 2008-2011
M.S. 2005-2008
B. S. 2001-2005
School of medicine, Washington University in Saint Louis
School of Traditional Chinese Medicine, China Pharmaceutical University
College of Pharmacy, Gansu University of Chinese Medicine
College of Pharmacy, Gansu University of Chinese Medicine
Working Experience
2011-present
Lecturer
School of Pharmacy, South-Central University for Nationalities
Research
Elucidating molecular mechanisms involved in gout and hyperuricemia; development of novel traditional medicines for hyperuricemia and gout.The focus of my laboratory is to investigate the hypouricemic effect of traditional medicines. According to the complicated pathogenesis of hyperuricemia and gout, we use rat, mouse and cells as the model system to screen the active medicines or components and to elucidate potential molecular mechanisms involved in hyperuricemia and gout. In addition, these models used in our studies have contributed to helping us obtain some research findings. For example, we find that Dolichos falcatus Klein and Smilax china L., two traditional medicines, may alleviate the uric acid level in hyperuricemia and inflammation in gout. Until to now, we have gained foundations by more than 10 research projects, published more than 50 papers. The selected projects and publications are listed as follow.
Grants
(1) Major new drug creation of Ministry of science and technology (2017BA20060007, 2017.1 ¬- 2020.12)
(2) National Nature Science Fund of China (8107384, 2013.1 -2016.12)
(3) Wuhan Science and Technology Youth Chengang Plan (2015070404010183, 2015.1-2016.12)
(4) National Nature Science Fund of Hubei (2016CFB617, 2016.1 -2017.12)
Selected Publications
1.Feng X, Zhong GJ, Deng Ba DJ, Yang B, Chen L*, Du S. Hepatoprotective effect of Herpetospermum caudigerum Wall. on carbon tetrachloride-induced hepatic fibrosis in rats. J Cell Mol Med. 2018 Apr 14. doi: 10.1111/jcmm.13568.
2.Lan Z, Xie G, Wei M, Wang P, Chen L*. The protective effect of Epimedii Folium and Curculiginis Rhizoma on Alzheimer's disease by the inhibitions of NF-κB/MAPK pathway and NLRP3 inflammasome. Oncotarget. 2017, 8(27):43709-43720
3.Chen L*, Lan Z. Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway. Food Funct. 2017, 8(5):1785-1792.
4.Lan Z, Hu C, Huang Y, Chen L*, Ma C, Mei Z, Lin Q, Huang X, Deng X. Safety assessment of saponins extract in Dolichos falcatus Klein: Subchronic study in Sprague-Dawley rats. J Ethnopharmacol. 174, 230-7, 2015.
5.Wei H, Hu C, Xie J, Yang C, Zhao Y, Guo Y, Mei Z, Chen L*, Lan Z. Doliroside A attenuates monosodium urate crystals-induced inflammation by targeting NLRP3 inflammasome. Eur J Pharmacol. 740, 321-8, 2014.
6.Deng X, Zhao X, Lan Z, Jiang J, Yin W, Chen L*. Anti-tumor effects of flavonoids from the ethnic medicine Docynia delavayi (Franch.) Schneid. and its possible mechanism. J Med Food.; 7:787-94, 2014.
7.Chen L, Zhao L, Zhang C, Lan Z. Protective effect of p-cymene on lipopolysaccharide-induced acute lung injury in mice. Inflammation 37, 358-64, 2014.
8.Chen L*, Mola M, Deng X, Mei Z, Huang X, Shu G, Wei L, Hou X, Lan Z*, Lin Q*. Dolichos falcata Klein attenuated the inflammation induced by monosodium urate crystals in vivo and in vitro. Journal of Ethnopharmacology 150, 545-52, 2013.
9.Chen L, Lan Z, Lin Q, Mi X, He Y, Wei L, Lin Y, Zhang Y, Deng X*. Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice. Food Chem Toxicol 52C, 28-35, 2013.
10.Chen L, Lan Z, Ma S, Zhao L, Yang X*. Attenuation of gouty arthritis by emodinol in monosodium urate crystal-treated mice. Plata Med 79, 634-8, 2013.
11.Chen L, Lan Z, Zhou Y, Li F, Zhang X, Zhang C, Yang Z, Li P. Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. Planta Medica 77, 1769-73, 2011.
12.Chen L, Yin H, Lan Z, Ma S, Zhang C, Yang Z, Li P, Lin B. Anti-hyperuricemic and nephroprotective effects of Smilax china L. Journal of Ethnopharmacology 135, 399-405, 2011.
Book
1. Traditional Chinese Medicine Processing Experiment and Guidance (2nd Edition), China Medical Science and Technology Press, Associate Editor
2. Traditional Chinese Medicine Processing (2nd Edition), China Medical Science and Technology Press, Editorial Board
3. Research Methodology of Chinese Herbal Medicine, People's Medical Publishing House, Author
