Date of Birth: September 1974
Ethnicity: Han
Title: Professor, Master's Supervisor in Pharmacy
Discipline/Field of Study: Pharmacology and Pharmacognosy
Research Interests:
Yin Shijin, Professor, Associate Dean, Master's Supervisor. He obtained his PhD in Microbiology from Wuhan University in 2009 and has conducted postdoctoral research in pharmacology and neurobiology at the University of Texas Health Science Center at Houston and Washington University in St. Louis. His primary research focuses on ion channel pharmacology, targeting disease-associated ion channel proteins to investigate the role of bioactive peptides and small organic molecules in the occurrence of sensory hypersensitivity (pain and itch) and autoimmune diseases.
He has discovered that transient receptor potential (TRP) channels TRPV1 and TRPA1 mediate pain hypersensitivity reactions induced by vitamin A analogs; demonstrated that human beta defensin 2 induces cytokine release through direct interaction with immune cell TLR4 receptors and acts on mouse dorsal root ganglia TRPV1 channels to cause itch; and elucidated the immune suppression mechanism mediated by the Kv1.3 channel involving peptides from scorpion and centipede venoms, as well as chalcone compounds from the traditional Dai medicine "Sanguis Draxonis."
He has hosted three projects funded by the National Natural Science Foundation, and has led or participated in over ten provincial and ministerial projects, including significant projects under the Ministry of Science and Technology. He has published over 80 research papers, including more than 40 papers in prestigious SCI journals indexed by Nature, such as Immunity, Nature Communications, and The Journal of Clinical Investigation. He holds four national invention patents and has received multiple accolades, including first and second prizes for scientific and technological progress from Hubei Province, as well as a second prize for teaching achievements in Hubei Province and a first prize for technological advancement from the Ethnic Medicine Association.
He is currently a board member and think tank expert of the China Ethnic Medicine Association, an executive member of the Hubei Province Traditional Chinese Medicine Association, a committee member of the Drug and Natural Products Committee of the Hubei Province Pharmacy Association, and a director of the Hubei Province Toxicology Society. He independently teaches several courses, including Biochemistry, Biochemistry Laboratory, and Anatomy and Physiology Laboratory.
Email: yinshijinyf@163.com
Major Provincial and Ministerial Research Projects Hosted or Participated In:
1. Hubei Natural Science Foundation Innovation Development Joint Fund Key Project
Project Number: 2024AFD262
Research on the Immune-Boosting Effect of the Qi-Invigorating Formula on Bladder Cancer Growth and Hospital Preparations
Duration: May 2024 - May 2027
Funding: 200,000 RMB
Status: Ongoing
Role: Principal Investigator
2. Key Subproject under the National Key R&D Program for Modernization of Traditional Chinese Medicine
Project Number: 2019YFC1712402
Efficacy Analysis and Modern Pharmacology Research of Classic Tibetan Medicines: Ruyi Treasure Tablets and Baimai Ointment
Duration: July 2019 - July 2023
Funding: 1,070,000 RMB
Status: Completed
Role: Subproject Principal Investigator
3. Project Commissioned by Enterprises and Institutions
Project Number: HZY19025
Total Synthesis of a Derivative of Dragon's Blood B and Its Efficacy Evaluation for Treating Rheumatoid Arthritis
Duration: August 2019 - July 2022
Funding: 200,000 RMB
Status: Ongoing
Role: Principal Investigator
4. Wuhan International Scientific and Technological Cooperation Program
Project Number: 2017030209020256
Mechanism of Kv1.3 Channel-Mediated Chalcone Compounds in Treating Autoimmune Diseases
Duration: June 2017 - December 2019
Funding: 200,000 RMB
Status: Completed
Role: Principal Investigator
5. Hubei Provincial Technology Innovation Special Project (Foreign Scientific and Technological Cooperation Type)
Project Number: 2017AHB067
International Collaborative Research on the Molecular Mechanism of Traditional Chinese Medicine for Itch Relief
Duration: June 2017 - December 2019
Funding: 300,000 RMB
Status: Ongoing
Role: Participant
6. National Natural Science Foundation Emergency Management Project
Project Number: 81641186
Kv1.3 Blockers in Dragon’s Blood and Their Role in Immune Regulation
Duration: January 2017 - December 2017
Funding: 100,000 RMB
Status: Completed
Role: Principal Investigator
7. Hubei Provincial Technology Innovation Major Project
Project Number: 2016ACA138
Key Technology Research on Designing, Producing, and Developing Applications for Bioactive Compound Libraries Derived from Natural Products
Duration: September 2016 - December 2018
Funding: 1,000,000 RMB
Status: Completed
Role: Participant
8. National Natural Science Foundation General Project
Project Number: 81373379
Investigation of Species Diversity of Chinese Centipedes and Transcriptomic Research on Medicinal Species
Duration: January 2014 - December 2017
Funding: 700,000 RMB
Status: Completed
Role: Principal Investigator
9. Hubei Provincial Natural Science Foundation General Project
Project Number: 2015CFB491
Research on the Mechanism of Dragon's Blood in Treating Autoimmune Diseases
Duration: April 2015 - April 2017
Funding: 30,000 RMB
Status: Completed
Role: Principal Investigator
10. Guangdong Provincial Science and Technology Department Industry-Academia-Research Integration Project
Project Number: 010B090400047
Application of Embedded Wireless Networks in ICU Clinical Information Systems
Duration: October 2010 - June 2013
Funding: 300,000 RMB
Status: Completed
Role: Principal Investigator
11. National Natural Science Foundation Youth Fund Project
Project Number: 30900239
Research on the Mechanism of BmαTX14 Peptide and Channel β Subunits in Regulating Sodium Channel Function
Duration: January 2010 - December 2012
Funding: 200,000 RMB
Status: Completed
Role: Principal Investigator
Research Publications
[1] Zhou YS, Tao HB, Lv SS, Liang KQ, Shi WY, Liu KY, Li YY, Chen LY, Zhou L, Yin SJ*, Zhao QR. Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice. Acta Pharmacol Sin. 2024 Oct;45(10):2045-2060.（SCI1区top，IF8.2，*Correspondence author）
[2] Zou Y, Zhao Q, Zhang X, Yu H, Zhou Y, Li Z, Xiao M, Xiang Q, Zhang L, Shi W, Tao H, Chen L, Han B, Yin S*. The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats. Front Immunol. 2023 Apr 24;14:1094649. doi: 10.3389/fimmu.2023.1094649. PMID: 37168850; PMCID: PMC10165104.（SCI2区，IF5.7，*Correspondence author）
[3] Zhao Q, Zhang X, Long S, Wang S, Yu H, Zhou Y, Li Y, Xue L, Hu Y, Yin S*. Licochalcone Mediates the Pain Relief by Targeting the Voltage-Gated Sodium Channel. Mol Pharmacol. 2023 Oct;104(4):133-143. doi: 10.1124/molpharm.122.000658. Epub 2023 Jul 7. PMID: 37419692.（SCI2区，IF4.05，*Correspondence author）
[4] Qiang Li , Peng Liu, Chen Wu , Lijie Bai , Zhongyun Zhang, Zilu Bao , Min Zou, Zhaoxiang Ren, Lin Yuan, Maochuan Liao, Zhou Lan, Shijin Yin*, Lvyi Chen* . Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia. J Ethnopharmacol. 2022, 298:115679. （SCI2区top，IF5.195，*Correspondence author）
[5] Zhang X, Zhao Q, Yang F, Lan Z, Li Y, Xiao M, Yu H, Li Z, Zhou Y, Wu Y, Cao Z, Yin S*. Mechanisms Underlying the Inhibition of KV1.3 Channel by Scorpion Toxin ImKTX58. Mol Pharmacol. 2022,102(3):150-160. （SCI2区，IF4.05，*Correspondence author）
[6] Shujuan Shi, Qianru Zhao , Caihua Ke, Siru Long , Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin*. Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels. Frontiers in Pharmacology, 2021, 12:685092.（SCI2区top，IF5.81，*Correspondence author）
[7]Yubiao Zhang, Feng Zhang, Shujuan Shi, Xinqiao Liu, Weisong Cai, Guangtao Han, Caihua Ke, Siru Long, Zhiyong Di, Shijin Yin*, Haohuan Li*. Immunosuppressive Effects of a Novel Potassium Channel Toxin Ktx-Sp2 from Scorpiops Pocoki. Cell Biosci. 2019, 9:99。（SCI3区，IF5.03，*Correspondence author）
[8]Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Shijin Yin, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS, Hu H. TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells.Immunity, 2018，49(1):107-119. (SCI1区，IF 19.734,).
[9]Luo J, Bavencoffe A, Yang P, Feng J, Shijin Yin, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, Hu H. Zinc inhibits TRPV1 to alleviate chemotherapy-induced neuropathic pain. J Neurosci. 2018, 38(2):474-483. (SCI1区，IF 5.988)
[10] Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Shijin Yin, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H. Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol. 2018, 141(2):608-619. (SCI1区，IF 13.06).
[11] Jing Feng, Jialie Luo, Madison R. Mack, Pu Yang, Feng Zhang, Guan Wang, Xuan Gong, Tao Cai, Zhinan Mei, Brian Kim, Shijin Yin*, Hongzhen Hu. The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice. Journal of Allergy and Clinical Immunology, 2017, 140(3):885-888. (SCI1区，IF 13.06, *通讯作者).
[12] Zou Y, Zhang F, Li Y, Wang Y, Li Y, Long Z, Shi S, Shuai L, Liu J, Di Z, Shijin Yin*. Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki. Cell & Bioscience. 2017, 7:60.（SCI3区, IF 5.03, *Correspondence author).
[13]Feng J, Yang P, Mack MR, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Shijin Yin, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017, 8(1):980. (SCI1区，IF 12.124).
[14] Kim S, Barry DM, Liu XY, Shijin Yin,et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.Sci Signal, 2016, 9(437):ra71.(SCI1区, IF 7.359)
[15] Shijin Yin，Yanning Qiu，Zhaohui Pan，Shaobin Li，Zhiyong Di . Chaerilus pseudoconchiformus sp. nov., a new species found in Xizang, and an updated key of the chaerilid scorpions from China (Scorpiones:Chaerilidae)，ZooKeys，2015，495：41-51.（SCI）
[16] Shijin Yin，Yunfeng Zhang，Zhaohui Pan，Shaobin Li，Zhiyong Di ，Scorpiops ingens sp.nov.,found in Xizang, and an updated key of Scorpions from China(Scorpiones:Euscorpidae, Scorpiopinae)，ZooKeys，2015，495：53-61。（SCI）
[17] Kimball C, Luo J, Shijin Yin, Hu H, Dhaka A.The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane. Mol Pharmacol, 2015, 88(1):131-8.（SCI, IF 3.931）
[18] Shijin Yin，Qinglan Hu，Jialie Luo，Yuxin Li，Chunlan Lu，XuanChen，Hongzhen Hu. Loureirin B, an essential component of Sanguis Draxonis,inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells，Cell & Bioscience，2014，4：78。（SCI3区, IF 5.03,Correspondence author）
[19] Shijin,Yin, Jialie Luo, Aihua Qian, Weihua Yu, Hongzhen Hu. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. Br J Pharmacol. 2014,171(6):1510-20 (SCI 2区，IF 5.06,Correspondence author)
[20] Shijin,Yin, Jialie Luo, Aihua Qian, Junhui Du, Qing Yang, Shentai Zhou, Weihua Yu, Guangwei Du, Richard B. Clark, Edgar T. Walters, Susan M. Carlton, and Hongzhen Hu. Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. The Journal of Clinical Investigation, 2013, 8:1-11 (SCI1区, IF 12.86)
[21] Feng J, Hu Y, Yi H, Shijin Yin, Han S, Hu J, Chen Z, Yang W, Cao Z, De Waard M, Sabatier JM, Li W, Wu Y. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013, 288(18):12544-53. (SCI 2区, IF 5.7)
[22] Dai, Hui1、Shijin Yin1、Li, Tian、Cao, Zhijian、Ji, Yonghua、Wu, Yingliang、Li, Wenxin. Recombinant expression, purification, and characterization of scorpion toxin Bm alpha TX14. Protein Expression and Purification, 2012,82(2): 325-331.(SCI, Co-First author)
[23] Na Gao, Jialie Luo, Karen Uray, Aihua Qian, Shijin Yin, Guodu Wang, Xiyu Wang, Yun Xia,Jackie D. Wood, Hongzhen Hu. CaMKII Is Essential for the Function of the Enteric Nervous System. PLoS One.2012;7(8):1-10.（SCI, IF 4.351 ）
[24] Chen Z,Hu Y,Han S,Shijin Yin,He Y,Wu Y,Cao Z,Li W. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. J Biochem Mol Toxicol.2011 ;25(4):244-51.(SCI)
[25] Song Han1, Shijin Yin1, Hong Yi. Ste´phanie Mouhat, Su Qiu, Zhijian Cao, Jean-Marc Sabatier, Yingliang Wu, and Wenxin Li. Protein-Protein Recognition Control by ModulatingElectrostaticInteractions. J Proteome Res, 2010, 9(6):3118-25（SCI 2区, IF 5.684, Co-First author）
[26] Di Z., Cao Z, Wu Y.,Shijin Yin., Gregory D and Li W. Discovery of the centipede family Plutoniumidae(Chilopoda) in Asia: a new species of Theatops from China, and the taxonomic value of spiracle distributions in Scolopendromorpha. Zootaxa, 2010, 2667:51-63.（SCI）
[27] Liu, J., Ma, Y., Shijin Yin., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W.,. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus. Peptides, 2009, 30(4):675-80. (SCI)
[28] Shijin Yin., Jiang L., Yi H., Han S., Yang D.W., Liu M.L., Liu H., Cao Z.J., Wu Y.L. & Li W.X. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels. J Proteome Res,2008, 7, 4890-4897.(SCI 2区, IF 5.67)
[29] Shijin Yin; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L., Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides, 2008，29（9）: 1514-20. (SCI)
[30] Han, S1.; Yi, H1.; Shijin Yin1.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem , 2008, 283, 19058-19065.(SCI 2区, IF 5.7, Co-First author)
[31] Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Shijin Yin.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W., A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. J Psychiatry Neurosci, 2008, 33, 43-46.(SCI)
[32] Wu, W1.; Shijin Yin1.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W., Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides, 2007, 28, 2306-2312.（SCI, Co-First author）
[33] Yi, H.; Cao, Z.; Shijin Yin.; Dai, C.; Wu, Y.; Li, W., Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res, 2007, 6, 611-620. (SCI, IF 5.67)
[34] Mao, X.; Cao, Z.; Shijin Yin.; Ma, Y.; Wu, Y.; Li, W., Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun, 2007, 360, 728-734.(SCI)
[35] Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.; Shijin Yin.; Yingliang, W.; Wenxin, L., Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides, 2006, 27, 1235-1240. (SCI）
[36] Zhijian, C.; Chao, D.; Shijin Yin.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L., Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. J Biochem Mol Toxicol, 2006, 20, 1-6.(SCI)
[37] Wang, K.;Shijin Yin; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. Biotechnol Lett, 2006, 28, 1767-1772.(SCI)
[38] Liu, X.; Shijin Yin.; Chen, S.; Ma, Q., Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons.Conf Proc IEEE Eng Med Biol Soc, 2005, 5, 4962-4965.(EI)
[39] Xiangming, L.; Su, C.; Shijin Yin.; Zhinan, M., Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. Sci China C Life Sci, 2004, 47, 340-348.(SCI)
Patents：
(1) Application of Dracaena cochinchinensis in the preparation of drugs for preventing and treating autoimmune diseases. Date: June 26, 2018. Chinese Invention Patent, Granted Patent Number: ZL 2014 1 0565812.0. First inventor.
(2) Derivative of Dragon's Blood Compound B and its preparation and application. Date: July 24, 2018. Chinese Invention Patent, Granted Patent Number: ZL 2017 1 0519342.8. First inventor.
(3) Method for preparing total flavonoids of Dracaena cochinchinensis and its application. Date: September 24, 2021. Chinese Invention Patent, Granted Patent Number: ZL 2019 1 0150187.6. First inventor.
(4) Multi-access point ZigBee network coordinator. Year: 2012. Chinese Utility Model Patent, Granted Patent Number: CN 201220123251.5. Second inventor.
(5) Human motion detector based on wireless communication. Year: 2012. Chinese Utility Model Patent, Granted Patent Number: CN 201120446464.7. Second inventor.
(6) Wireless pulse detector based on ZigBee. Year: 2012. Chinese Utility Model Patent, Granted Patent Number: CN 201120446500.X. Second inventor.
(7) Gene engineering immunosuppressive peptides and preparation methods and uses. Year: 2009. Chinese Invention Patent, Granted Patent Number: CN 101423550B. Fifth inventor.
