Education
Ph.D., State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 2013-2016
M.S., Xiangya School of Pharmaceutical Sciences, Central South University, 2009-2012
B.S., College of Pharmacy, Jining Medical University, 2005-2009
Professional Profile
2016-: Lecturer, School of Pharmaceutical Sciences, South-Central University for Nationalities
2012-2013: Talent assistant, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences,
Research Interests
My research focuses on complex carbohydrates, especially isolation, purification, structural elucidation, bioactivities of polysaccharides and oligosaccharides from natural sources, and new drug discovery based on natural bioactive glycans.
Major Research Progress
Based on the "bottom up" strategy, the precise structures of native FGs from various species of sea cucumber have been well-defined by the preparation of depolymerized products and the purification and structural analysis of the resulting oligosaccharides. A series of pure FG-derived oligosaccharides with different reducing or non-reducing end residues and their derivatives with structural modification were obtained for investigation of the pharmacological activity and structure-activity relationships.
Publications in Recent Years:
1#, Na Gao1#, Ronghua Yin, Lisha Lin, Chuang Xiao, Lutan Zhou, Zi Li, Steven W. Purcell, Mingyi Wu, Jinhua Zhao. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors. [4] Na Gao, Feng Lu, Chuang Xiao, Lian Yang, Jun Chen, Kai Zhou, Dandan Wen, Zi Li, Mingyi Wu, Jianmin Jiang, Guangming Liu*, Jinhua Zhao*. β-Eliminative Depolymerization of the Fucosylated Chondroitin Sulfate and Anticoagulant Activities of Resulting Fragments. Carbohydrate Polymers, 2015, 127: 427–437.
[5] Na Gao, Mingyi Wu, Shao Liu, Wu Lian, Zi Li, Jinhua Zhao*. Preparation and characterization of O-acylated fucosylated chondroitin sulfate from sea cucumber. Marine Drugs, 2012, 10, 1647–1661.
[6] Mingyi Wu, Dandan Wen, Na Gao, Chuang Xiao, Lian Yang, Li Xu, Wu Lian, Wenlie, Peng, Jianmin Jiang*, Jinhua Zhao*. Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase. European Journal of Medicinal Chemistry, 2015, 92, 257–269.
Selected Authorized Invention Patent:
[1] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. US 9896517b2 [The United States authorized, 2018-02-20]
[2] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low-molecular-weight-glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. License 6293862 [Japan authorized, 2018-02-23]
[3] Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low-molecular-weight- glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivate thereof. License 6248179 [Japan authorized, 2017-11-24]
[4] Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Li Z, Lu F, Xu L, Xiao C, Yang L, Chen J, Zhou LT, Peng WL, Liu JK. Fuc3S4S substituted oligoglycosaminoglycan and preparation method thereof. WO 2015/103921 A1
[5] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Derivate of low molecular weight fucosylated glycosaminoglycan and medical composition and preparation method and application thereof. CN 103145868 B
[6] Liu JK, Zheng YT, Zhao JH, Wu MY, Huang N, Li Z, Gao N, Wen DD, Lian W, He JB. Low molecular weight carboxyl-reduced derivatives of fucosylated glycosaminoglycans and preparation method and applications of low molecular weight carboxyl-reduced derivatives. CN 102558389 B
[7] Zhao JH, Wu MY, Gao N, Wen DD, Lian W, Li Z. Fucosylated glycosaminoglycan derivative and preparation method thereof. CN 102329397 B
[8] Zhao JH, He JX, Wu MY, Zhao LY, Liu ZW, Yang L, Li Z, Gao N, Xiao C, Xu L, Chen J, Zhou LT. Oligosaccharide compound inhibiting endogenous factor X enzyme activity and pharmaceutical composition thereof. CN 104370980 B
[9] Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. 2,5-anhydrated talose or derivatives thereof terminal low-molecular-weight glycosaminoglycan derivative. CN 103214591 B
[10] Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Li Z, Lu F, Xu L, Xiao C, Yang L, Chen J, Zhou LT, Peng WL, Liu JK. Fuc3S4S substituted oligo-glycosaminoglycan and preparation method thereof. CN 103788222 B
Grants
