Professor
School of Pharmaceutical Sciences
South-Central University for Nationalities
182 Minzu Avenue, Wuhan，Hubei, 430074, P.R.China
Tele: +86-15087127510;
E-mail Address:2015084@mail.kib.ac.cn
Education:
2001-2004 Ph.D, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), Shanghai, China (Supervisor: Prof. Shengming Ma)
1998-2001 M.S,Lanzhou University, China (Supervisor: Prof. Yong-Qiang Tu)
1994-1998 B.S,Lanzhou University, China
Academic Career:
12/2016-present Professor, South-Central University for Nationalities, China
09/2010-12/2016 Professor, Kunming Institute of Botany, CAS, China
12/2005-08/2010 Postdoctoral Fellow, Ohio State University,
Supervisor: Prof. T.V.RajanBabu
08/2004-11/2005Postdoctoral Fellow, University of Nebraska-Lincoln,
Supervisor: Prof. David B. Berkowitz
Awards:
1. Candidate of “Hundred Talents Project” of Chinese Academy of Science, 2011
2. Candidate of “High skilled personnel introduction program of Yunnan Province”, 2011
Research Interests:
1. The development of sustainable methodologies for the total synthesis of natural products, synthesis of libraries of small molecules for wide biological screening
2. Asymmetric catalyzed reaction study
3. Transition metal catalyzed reaction study
Selected Publications:
1. Wen-Wu Sun, Ji-Kai Liu* and Bin Wu*. Practical synthesis of polysubstituted unsymmetric 1,10-phenanthrolines by palladium catalyzed intramolecular oxidative cross coupling of C(sp2)– H and C(sp3)–H bonds of carboxamides. Org. Chem. Front. 2019, 6, 544.
2. Jie Zhao, Xiao-Jing Zhao, Pei Cao, Ji-Kai Liu,* and Bin Wu*. Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)−H Bonds. Org.Lett. 2017, 19, 4880.
3. Dongdong Xu, Wen-Wu Sun, Yanli Xie, Ji-Kai Liu,*, Bin Liu,*, Yingbi Zhou,* and Bin Wu*. Free Regioselective Hypervalent Iodine-Mediated C‑2 and C‑3 Difunctionalization of N‑Substituted Indoles. J. Org. Chem. 2016, 81, 11081.
4. Shi-Jin Zhang, Wen-Wu Sun, Pei Cao,* Xiao-Ping Dong,*, Ji-Kai Liu, and Bin Wu*. Stereoselective Synthesis of Diazabicyclic β‑Lactams through Intramolecular Amination of Unactivated C(sp3)−H Bonds of Carboxamides by Palladium Catalysis. J. Org. Chem. 2016, 81, 956.
5. Wen-Wu Sun, Pei Cao, Ren-Qiang Mei, Yue Li, Yuan-Liang Ma, and Bin Wu*. Catalyzed Unactivated C(sp3)−H Bond Activation and Intramolecular Amination of Carboxamides: A New Approach to β‑Lactams. Org.Lett. 2014, 16, 480.
6. Bin Wu, Jon R. Parquette*, and T. V. RajanBabu*. Regiodivergent Ring Opening of Chiral Aziridines. Science. 2009, 326, 1662.
7. Bin Wu, Judith C. Gallucci, Jon R. Parquette*, and T. V. RajanBabu*. Enantioselective Desymmetrization of meso-Aziridines with TMSN3 or TMSCN Catalyzed by Discrete Yttrium Complexes. Angew. Chem. Int. Ed. 2009, 48, 1126.
8. Nicola J. Baxter, Matthew W. Bowler, Tooba Alizadeh, Matthew J. Cliff, Andrea M. Hounslow, Bin Wu, David B. Berkowitz, Nicholas H. Williams, Steven J. Gamblin, G. Michael Blackburn,* and Jonathan P. Waltho.* MgF3 is shown to be an isoelectronic phosphorane transition state mimic of enzymatic phosphoryl transfer by 19F NMR and X-ray analysis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 4555.
9. David B. Berkowitz*, Bin Wu, and Huijie Li. A Formal [3,3]-sigmatropic Rearrangement Route to Quaternary 10. Shengming Ma*, Bin Wu, Xuefeng Jiang, and Shimin Zhao. Studies on Pd (II)-Catalyzed Synthesis of (Z)-b-lactones from Cyclocarbonylation of 2-Alkynols and the Subsequent Coupling Reactions. J. Org. Chem. 2005, 70, 2568.
11. Shengming Ma*, Bin Wu, and Xuefeng Jiang. PdCl2-Catalyzed Efficient Transformation of Propargylic Amines to (E)-b-lactams. J. Org. Chem. 2005, 70, 2588.
12. Shengming Ma*, Bin Wu, and Zhangjie Shi. An Efficient Synthesis of 4-Halo-5-hydroxyfuran-2(5H)-ones via the Sequential Halolactonization and 13. Shengming Ma*, Bin Wu, and Shimin Zhao. A Mild and Efficient Synthesis of (Z)-b-lactones via the PdCl2-Catalyzed Cyclocarbonylation of 2-Alkynols. Org.Lett. 2003, 5, 4429.
14. Yan Xing Jia, Bin Wu, Xin Li, Shi Kuo Ren, Yong Qiang Tu,* Albert S. C. Chen, and William Kitching. Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Stereocontrolled Synthetic Approach to the Key Mother Spiroketals. Org.Lett. 2001, 3, 847.
15. Xin Li, Bin Wu, Xue Zhi Zhao, Yan Xing Jia, Yong Qiang Tu,* De Run Li. An Interesting AlEt3-Promoted Stereoselective Tandem Rearrangement / Reduction of 16. Yan Xing Jia, Xin Li, Bin Wu, Xue Zhi Zhao, and Yong Qiang Tu.* A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals. Tetrahedron, 2002, 58, 1697.
