Yu-Sang Li
Professor
E-mail :liys2006@mail.scuec.edu.cn
Team Website: http:/s/53/t/1559/94/d7/info103639.htm
Tel: 86-27- 67842332
uCurriculum Vitae
•Hunan College of Traditional Chinese Medicine, Clinical medicine, 1997
•Hiroshima University, Hiroshima, Japan, M.D., 2006
•HiroshimaUniversityHospital, Hiroshima, Japan, Researcher Assistant, 2006-2007
•HiroshimaUniversity, Hiroshima, Japan, Visiting Researcher, 2008-2009
•South-CentralUniversity for Nationalities, Associate Professor, 2009-2016
•South-CentralUniversity for Nationalities, Professor, since 2016
uResearch Interests
•Molecular mechanism of liver cancer;
•Pharmacological research on anti-cancer, anti-inflammatory and analgesic activity of Traditional Chinese Medicine;
•Mechanism of chronic pain.
uAssociation and Awards
•The Japan Breast Cancer Society, Member;
•The Japanese Society of Pathology, Member;
•The first prize, the 13th general meeting of Japan Breast Cancer Society, 2005;
•The first prize, the 8th excellent thesis award of Japan Breast Cancer Society, 2007
uRepresentative Publications (*Corresponding author)
1.Zhang MT, Ye XX, Lan W, Yang YL, Wu T, Li YS*, Tang HB.Strategic combination of isocratic and gradient elution for simultaneous separation of polar compounds in traditional Chinese medicines by HPLC.Journal of Analytical Methods in Chemistry, 2018 (2018): 7569283, doi.org/10.1155/2018/7569283.
2.Chen MT, Yang YJ, Li YS, Li XJ, Zhang WK, Wang JP, Wang X, Tian GH, Tang HB*. Shengfu oil enhances the healing of full-thickness scalded skin accompanying the differential regulation of β-Catenin, Dlk1, and COX-2. Frontiers in Pharmacology. 2017 Nov 6; 8: 801. doi: 10.3389/fphar.2017.00801. eCollection 2017.
3.Ning D, Zhang WK, Tian H, Li XJ, Liu M, Li YS*, Tang HB. The involvement of β-Catenin/COX-2/VEGF axis in NMDA-caused retinopathy. Journal of Ophthalmology. 2017; 2017: 9760501. doi: 10.1155/2017/9760501.
4.Li XJ, Mu YM, Qin QF, Zeng ZX, Li YS, Zhang WK, Tang HB*, Tian GH, Shang HC. Chronic high-dosage fish oil exacerbates gut-liver axis injury in alcoholic steatohepatitis in mice: The roles of endotoxin and IL-4 in Kupffer cell polarization imbalance. Toxicology Research. 2017, 6, 611-620.DOI: 10.1039/C7TX00037E
5.Zhang WK, Gu HW, Li XJ, Li YS, Tang HB*, Tian GH, Shang HC. The dark side of the force - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice. Nanomedicine: Nanotechnology, Biology, and Medicine. 2017, 13(2): 701-711. doi: 10.1016/j.nano.2016.09.017.
6.Li YS, Leng CL, Chen MT, Zhang WK, Li XJ, Tang HB*, Shang HC, Zhu LH. Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway. Toxicology Research. 2016, 5:210-223.
7.Li XJ, Yang YJ, Li TT, Li YS, Zhang WK, Tang HB*. α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. Journal of Ethnopharmacology. 2016, 179:22-26.
8.Yang YL, Ye XX, Li YS*, Tan ZF, Jiang JZ. Determination of Morphine in Pharmaceutical Products by On-Line Solid-Phase Extraction and High-Performance Liquid Chromatography. Analytical Letters. 2016, 49: 1303-1309, doi.org/10.1080/00032719.2015.1101603.
9.Li XJ, Mu YM, Li TT, Yang YL, Zhang MT, Li YS, Zhang WK, Tang HB*, Shang HC. Gynura procumbens reverses acute and chronic ethanol-induced liver steatosis through MAPK/SREBP-1c-dependent and -independent pathways. Journal of Agricultural and Food Chemistry. 2015, 63(38):8460-8471.
10.Li YS, Xi Y, Li XJ, Leng CL, Jia MM, Zhang WK, Tang HB*. Up-regulation of the biosynthesis and release of substance P through Wnt/β-catenin signaling pathway in rat dorsal root ganglion cells. PLoS One. 2015, 10(6): e0129701.
11.Zhao XJ, Chen Q, Li YS*, Tang HB, Liu W, Yang XL. Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. European Journal of Pharmaceutics and Biopharmaceutics. 2015, 93: 27-36.
12.Zhao XJ, Chen Q, Liu W, Li YS*, Tang HB, Liu XH, Yang XL. Co-delivery of doxorubicin and curcumin withlipid nanoparticles results in improved efficacy of chemotherapy in liver cancer. International Journal of Nanomedicine. 2015, 10: 257–270.
13.Li YS, Chen BF, Li XJ, Zhang WK, Tang HB*. Cytotoxicity of polyaniline nanomaterial on rat celiac macrophages in vitro. PLoS One. 2014, 9(9):e107361.
14.Li XJ, Jia MM, Li YS*, Yang YL, Mao XQ, Tang HB. Involvement of substance p/neurokinin-1 receptor in the analgesic and anticancer activities of minimally toxic fraction from the traditional Chinese medicine Liu-Shen-Wan in vitro. Biological and Pharmaceutical Bulletin. 2014, 37(3):431-438.
15.Xi Y, Li YS*, Tang HB. High mobility group A1 protein acts as a new target of Notch1 signaling and regulates cell proliferation in T leukemia cells. Molecular and Cellular Biochemistry. 2013, 374: 173-180.
16.Li YS, Wang JX, Jia MM, Liu M, Li XJ, Tang HB*. Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats. Journal of Pharmacological Sciences. 2012,118: 43-54.
17.Li YS, Liu M, Nakata Y, Tang HB. β-Catenin accumulation in nuclei of hepatocellular carcinoma cells up-regulates glutathione-s-transferase M3 mRNA. World Journal of Gastroenterology. 2011, 17:1772.
18.Luo W, Li YS*, Yuan J, Zhu LH, Liu ZD, Tang HQ. Ultrasensitive fluorometric determination of hydrogen peroxide and glucose by using multiferroic BiFeO3 nanoparticles as a catalyst. Talanta. 2010, 81: 901.
19.Li YS, Kaneko M, Amatya VJ, Takeshima Y, Arihiro K, Inai K*. Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast. Pathology International. 2006, 56 : 256.
20.Li YS, Kaneko M, Sakamoto DG, Takeshima Y, Inai K*. The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast. Breast Cancer. 2006, 13: 58.
uRepresentative Grants
1.Grant from National Natural Science Foundation of China: Protective mechanisms of Gynura procumbens against liver cancer through the inhibition of inflammatory feedback loop of “β-catenin/COX-2, No. 81673711, 2016;
2.Grant from National Natural Science Foundation of China: A study on the mechanism of cancer pain relief by Liu-Shen-Wan through the inhibition of the β-catenin and COX-2 regulatory loop, No. 81573887, 2015;
3.Grant from National Natural Science Foundation of China: Moduation mechanism of Huoxuequyu Compound on diabetic retinopathy base on Wnt/β-catenin signaling pathway, No. 81202942, 2012;
4.Grant from National Natural Science Foundation of China: The regulatory role of Wnt/β-catenin signaling pathway in the development of primary hepatocellular carcinoma, No. 81101538, 2011;
5.Grant from National Natural Science Foundation of China: The role of non-neuronal cells in the regulation of substance P release from dorsal root ganglion neurons, No. 81070887, 2010;
6.Tackle Key Projects in Science and Technology of Wuhan city, China: Pre-clinical research of Dadou JiangTangWan on type II diabetes treatment, No. 201060623266, 2010
